CDB15:0001577 WNT1 — LRP5

Experimentally validated in Human, Mixed species; Orthology-inferred in Human, Mouse, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway.

Molecular cell, 2001; PubMed, Mus Musculus Wnt1 — Homo sapiens LRP5
ABSTRACT: To understand how the Wnt coreceptor LRP-5 is involved in transducing the canonical Wnt signals, we identified Axin as a protein that interacts with the intracellular domain of LRP-5. LRP-5, when expressed in fibroblast cells, showed no effect on the canonical Wnt signaling pathway by itself, but acted synergistically with Wnt. In contrast, LRP-5 mutants lacking the extracellular domain functioned as constitutively active forms that bind Axin and that induce LEF-1 activation by destabilizing Axin and stabilizing beta-catenin. Addition of Wnt caused the translocation of Axin to the membrane and enhanced the interaction between Axin and LRP-5. In addition, the LRP-5 sequences involved in interactions with Axin are required for LEF-1 activation. Thus, we conclude that the binding of Axin to LRP-5 is an important part of the Wnt signal transduction pathway.

Distinct roles of LRP5 and LRP6 in Wnt signaling regulation in the retina.

Biochemical and biophysical research communications, 2021; PubMed, Homo sapiens WNT1 — Homo sapiens LRP5
ABSTRACT: Dysregulation of Wnt signaling is implicated in multiple ocular disorders. The roles of Wnt co-receptors LRP5 and LRP6 in Wnt signaling regulation remain elusive, as most retinal cells express both of the co-receptors. To address this question, LRP5 and LRP6 were individually knocked-out in a human retinal pigment epithelium cell line using the CRISPR-Cas9 technology. Wnt signaling activity induced by various Wnt ligands was measured using wild-type and the KO cell lines. The results identified three groups of Wnt ligands based on their co-receptor specificity: 1) activation of Wnt signaling only through LRP6, 2) through both LRP5 and LRP6 and 3) predominantly through LRP5. These results indicate that LRP5 and LRP6 have differential roles in Wnt signaling regulation.
Basic Information on WNT1
Ligand Name: Wnt family member 1
Other Symbols: INT1
Ligand Location: secreted based on perplexity, uniprot
HGNC Gene Symbol Report: WNT1
GeneCards: WNT1
Functional Annotations for WNT1
Gene Ontologies: PAN-GO, AmiGO 2
Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)
Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)
Interactions with other Receptors for WNT1
WNT1 — FZD1 ・ WNT1 — FZD3 ・ WNT1 — FZD5 ・ WNT1 — FZD7 ・ WNT1 — FZD8 ・ WNT1 — LRP6 ・ WNT1 — RYK ・ WNT1 — FZD10 ・ WNT1 — FZD2 ・ WNT1 — FZD4 ・ WNT1 — ROR2 ・ WNT1 — FZD6
Basic Information on LRP5
Receptor Name: LDL receptor related protein 5
Other Symbols: LRP7, OPPG, EVR1, LR3, BMND1, HBM, OPS, OPTA1, VBCH2, EVR4
Receptor Location: cell membrane based on perplexity
HGNC Gene Symbol Report: LRP5
GeneCards: LRP5
Functional Annotations for LRP5
Gene Ontologies: PAN-GO, AmiGO 2
Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)
Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)
Interactions with other Ligands for LRP5
APOE — LRP5 ・ DKK1 — LRP5 ・ SOST — LRP5 ・ WNT5A — LRP5 ・ WNT7B — LRP5 ・ WNT16 — LRP5 ・ SELENOP — LRP5 ・ TGM2 — LRP5 ・ WNT10B — LRP5 ・ WNT2 — LRP5 ・ WNT3 — LRP5 ・ WNT3A — LRP5 ・ WNT4 — LRP5 ・ WNT7A — LRP5 ・ WNT9A — LRP5 ・ WNT9B — LRP5
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