CDB25:0004535 WNT9A — LRP5

Experimentally validated in Human; Orthology-inferred in Mouse, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

Distinct roles of LRP5 and LRP6 in Wnt signaling regulation in the retina.

Biochemical and biophysical research communications, 2021; PubMed, Homo sapiens WNT9A — Homo sapiens LRP5

ABSTRACT: Dysregulation of Wnt signaling is implicated in multiple ocular disorders. The roles of Wnt co-receptors LRP5 and LRP6 in Wnt signaling regulation remain elusive, as most retinal cells express both of the co-receptors. To address this question, LRP5 and LRP6 were individually knocked-out in a human retinal pigment epithelium cell line using the CRISPR-Cas9 technology. Wnt signaling activity induced by various Wnt ligands was measured using wild-type and the KO cell lines. The results identified three groups of Wnt ligands based on their co-receptor specificity: 1) activation of Wnt signaling only through LRP6, 2) through both LRP5 and LRP6 and 3) predominantly through LRP5. These results indicate that LRP5 and LRP6 have differential roles in Wnt signaling regulation.

Basic Information on WNT9A

Ligand Name: Wnt family member 9A

Other Symbols: WNT14

Ligand Location: secreted based on perplexity, uniprot

HGNC Gene Symbol Report: WNT9A

GeneCards: WNT9A

HGNC Gene Group: MicroRNA host genes, Receptor ligands: Wnt family

Functional Annotations for WNT9A

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for WNT9A

WNT9A — FZD10 ・ WNT9A — FZD4 ・ WNT9A — EGFR ・ WNT9A — FZD1 ・ WNT9A — FZD5 ・ WNT9A — FZD8 ・ WNT9A — FZD9 ・ WNT9A — LRP6 ・ WNT9A — MUSK

Basic Information on LRP5

Receptor Name: LDL receptor related protein 5

Other Symbols: LRP7, OPPG, EVR1, LR3, BMND1, HBM, OPS, OPTA1, VBCH2, EVR4

Receptor Location: cell membrane based on perplexity

HGNC Gene Symbol Report: LRP5

GeneCards: LRP5

HGNC Gene Group: Low density lipoprotein receptors

Functional Annotations for LRP5

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for LRP5

APOE — LRP5 ・ DKK1 — LRP5 ・ SOST — LRP5 ・ WNT1 — LRP5 ・ WNT5A — LRP5 ・ WNT7B — LRP5 ・ WNT16 — LRP5 ・ SELENOP — LRP5 ・ TGM2 — LRP5 ・ WNT10B — LRP5 ・ WNT2 — LRP5 ・ WNT3 — LRP5 ・ WNT3A — LRP5 ・ WNT4 — LRP5 ・ WNT7A — LRP5 ・ WNT9B — LRP5