CDB15:0000442 DKK1 — LRP5

Experimentally validated in Human; Orthology-inferred in Mouse, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6.

Current biology : CB, 2001; PubMed, Homo sapiens DKK1 — Homo sapiens LRP5

ABSTRACT: Dickkopf-1 (Dkk-1) is a head inducer secreted from the vertebrate head organizer and induces anterior development by antagonizing Wnt signaling. Although several families of secreted antagonists have been shown to inhibit Wnt signal transduction by binding to Wnt, the molecular mechanism of Dkk-1 action is unknown. The Wnt family of secreted growth factors initiates signaling via the Frizzled (Fz) receptor and its candidate coreceptor, LDL receptor-related protein 6 (LRP6), presumably through Fz-LRP6 complex formation induced by Wnt. The significance of the Fz-LRP6 complex in signal transduction remains to be established.

Basic Information on DKK1

Ligand Name: dickkopf Wnt signaling pathway inhibitor 1

Other Symbols: SK, DKK-1

Ligand Location: secreted based on perplexity, uniprot

HGNC Gene Symbol Report: DKK1

GeneCards: DKK1

HGNC Gene Group: unknown

Functional Annotations for DKK1

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for DKK1

DKK1 — KREMEN1 ・ DKK1 — KREMEN2 ・ DKK1 — LRP6 ・ DKK1 — LRP4 ・ DKK1 — CKAP4

Basic Information on LRP5

Receptor Name: LDL receptor related protein 5

Other Symbols: LRP7, OPPG, EVR1, LR3, BMND1, HBM, OPS, OPTA1, VBCH2, EVR4

Receptor Location: cell membrane based on perplexity

HGNC Gene Symbol Report: LRP5

GeneCards: LRP5

HGNC Gene Group: Low density lipoprotein receptors

Functional Annotations for LRP5

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for LRP5

APOE — LRP5 ・ SOST — LRP5 ・ WNT1 — LRP5 ・ WNT5A — LRP5 ・ WNT7B — LRP5 ・ WNT16 — LRP5 ・ SELENOP — LRP5 ・ TGM2 — LRP5 ・ WNT10B — LRP5 ・ WNT2 — LRP5 ・ WNT3 — LRP5 ・ WNT3A — LRP5 ・ WNT4 — LRP5 ・ WNT7A — LRP5 ・ WNT9A — LRP5 ・ WNT9B — LRP5