CDB25:0004488 WNT3A — LRP5

Experimentally validated in Mixed species; Orthology-inferred in Human, Mouse, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway.

Molecular cell, 2001; PubMed, Mus Musculus Wnt3a — Homo sapiens LRP5
ABSTRACT: To understand how the Wnt coreceptor LRP-5 is involved in transducing the canonical Wnt signals, we identified Axin as a protein that interacts with the intracellular domain of LRP-5. LRP-5, when expressed in fibroblast cells, showed no effect on the canonical Wnt signaling pathway by itself, but acted synergistically with Wnt. In contrast, LRP-5 mutants lacking the extracellular domain functioned as constitutively active forms that bind Axin and that induce LEF-1 activation by destabilizing Axin and stabilizing beta-catenin. Addition of Wnt caused the translocation of Axin to the membrane and enhanced the interaction between Axin and LRP-5. In addition, the LRP-5 sequences involved in interactions with Axin are required for LEF-1 activation. Thus, we conclude that the binding of Axin to LRP-5 is an important part of the Wnt signal transduction pathway.
Basic Information on WNT3A
Ligand Name: Wnt family member 3A
Other Symbols: N/A
Ligand Location: secreted based on hpa, perplexity, uniprot
HGNC Gene Symbol Report: WNT3A
GeneCards: WNT3A
Functional Annotations for WNT3A
Gene Ontologies: PAN-GO, AmiGO 2
Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)
Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)
Interactions with other Receptors for WNT3A
WNT3A — FZD1 ・ WNT3A — FZD2 ・ WNT3A — FZD5 ・ WNT3A — FZD6 ・ WNT3A — FZD7 ・ WNT3A — FZD8 ・ WNT3A — LRP6 ・ WNT3A — RYK ・ WNT3A — FZD10 ・ WNT3A — APP ・ WNT3A — FZD3 ・ WNT3A — FZD4 ・ WNT3A — GPC3 ・ WNT3A — GPC5 ・ WNT3A — LGR5 ・ WNT3A — PTK7
Basic Information on LRP5
Receptor Name: LDL receptor related protein 5
Other Symbols: LRP7, OPPG, EVR1, LR3, BMND1, HBM, OPS, OPTA1, VBCH2, EVR4
Receptor Location: cell membrane based on perplexity
HGNC Gene Symbol Report: LRP5
GeneCards: LRP5
Functional Annotations for LRP5
Gene Ontologies: PAN-GO, AmiGO 2
Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)
Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)
Interactions with other Ligands for LRP5
APOE — LRP5 ・ DKK1 — LRP5 ・ SOST — LRP5 ・ WNT1 — LRP5 ・ WNT5A — LRP5 ・ WNT7B — LRP5 ・ WNT16 — LRP5 ・ SELENOP — LRP5 ・ TGM2 — LRP5 ・ WNT10B — LRP5 ・ WNT2 — LRP5 ・ WNT3 — LRP5 ・ WNT4 — LRP5 ・ WNT7A — LRP5 ・ WNT9A — LRP5 ・ WNT9B — LRP5
← CDB25 WNT3A LGR5
CDB25 WNT3A PTK7 →