CDB25:0004471 WNT2 — LRP5

Experimentally validated in Human; Orthology-inferred in Mouse, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

Distinct roles of LRP5 and LRP6 in Wnt signaling regulation in the retina.

Biochemical and biophysical research communications, 2021; PubMed, Homo sapiens WNT2 — Homo sapiens LRP5
ABSTRACT: Dysregulation of Wnt signaling is implicated in multiple ocular disorders. The roles of Wnt co-receptors LRP5 and LRP6 in Wnt signaling regulation remain elusive, as most retinal cells express both of the co-receptors. To address this question, LRP5 and LRP6 were individually knocked-out in a human retinal pigment epithelium cell line using the CRISPR-Cas9 technology. Wnt signaling activity induced by various Wnt ligands was measured using wild-type and the KO cell lines. The results identified three groups of Wnt ligands based on their co-receptor specificity: 1) activation of Wnt signaling only through LRP6, 2) through both LRP5 and LRP6 and 3) predominantly through LRP5. These results indicate that LRP5 and LRP6 have differential roles in Wnt signaling regulation.
Basic Information on WNT2
Ligand Name: Wnt family member 2
Other Symbols: INT1L1, IRP
Ligand Location: secreted based on hpa, perplexity, uniprot
HGNC Gene Symbol Report: WNT2
GeneCards: WNT2
Functional Annotations for WNT2
Gene Ontologies: PAN-GO, AmiGO 2
Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)
Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)
Interactions with other Receptors for WNT2
WNT2 — FZD1 ・ WNT2 — FZD5 ・ WNT2 — FZD8 ・ WNT2 — FZD9 ・ WNT2 — LRP6 ・ WNT2 — FZD2 ・ WNT2 — FZD4 ・ WNT2 — FZD6
Basic Information on LRP5
Receptor Name: LDL receptor related protein 5
Other Symbols: LRP7, OPPG, EVR1, LR3, BMND1, HBM, OPS, OPTA1, VBCH2, EVR4
Receptor Location: cell membrane based on perplexity
HGNC Gene Symbol Report: LRP5
GeneCards: LRP5
Functional Annotations for LRP5
Gene Ontologies: PAN-GO, AmiGO 2
Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)
Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)
Interactions with other Ligands for LRP5
APOE — LRP5 ・ DKK1 — LRP5 ・ SOST — LRP5 ・ WNT1 — LRP5 ・ WNT5A — LRP5 ・ WNT7B — LRP5 ・ WNT16 — LRP5 ・ SELENOP — LRP5 ・ TGM2 — LRP5 ・ WNT10B — LRP5 ・ WNT3 — LRP5 ・ WNT3A — LRP5 ・ WNT4 — LRP5 ・ WNT7A — LRP5 ・ WNT9A — LRP5 ・ WNT9B — LRP5
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