CDB15:0001580 WNT2 — FZD1

Experimentally validated in Human; Orthology-inferred in Mouse, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response.

Oncogene, 1999; PubMed, Homo sapiens WNT2 — Homo sapiens FZD1
ABSTRACT: The human homologue of fz1 (Hfz1) was cloned from a cDNA library. Hfz1 was shown to couple to Wnt signal transduction pathways by its ability to enhance Wnt induced TCF dependent transcription in both autocrine and paracrine modes. Enhanced TCF dependent signaling was dose dependent with respect to both Wnt-3A and Hfz1. Moreover, Hfz1 deletion mutants with truncated carboxy termini showed markedly reduced capacity to enhance Wnt signal transduction. Specificity was demonstrated with respect to signal transduction by different Wnts. While Wnt-3a, -3, -1 and to a lesser extent Wnt-2 cooperated with Hfz1 in the paracrine assay for TCF dependent signaling, neither Wnt-4, -5a, -5b, -6, -7a nor -7b did so, despite similar levels of expression. However, coimmunoprecipitation of Hfz1 with both Wnt-3a and Wnt-5a indicated that TCF dependent signaling in response to Wnts is not determined solely by their ability to bind the receptor. All of these findings provide strong evidence that Hfz1 is a functional partner for certain Wnts in inducing TCF dependent transcription.
Basic Information on WNT2
Ligand Name: Wnt family member 2
Other Symbols: INT1L1, IRP
Ligand Location: secreted based on hpa, perplexity, uniprot
HGNC Gene Symbol Report: WNT2
GeneCards: WNT2
Functional Annotations for WNT2
Gene Ontologies: PAN-GO, AmiGO 2
Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)
Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)
Interactions with other Receptors for WNT2
WNT2 — FZD5 ・ WNT2 — FZD8 ・ WNT2 — FZD9 ・ WNT2 — LRP6 ・ WNT2 — FZD2 ・ WNT2 — FZD4 ・ WNT2 — FZD6 ・ WNT2 — LRP5
Basic Information on FZD1
Receptor Name: frizzled class receptor 1
Other Symbols: DKFZp564G072, Hfz1
Receptor Location: cell membrane based on hpa, perplexity, uniprot
HGNC Gene Symbol Report: FZD1
GeneCards: FZD1
HGNC Gene Group: 7TM proteins
Functional Annotations for FZD1
Gene Ontologies: PAN-GO, AmiGO 2
Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)
Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)
Interactions with other Ligands for FZD1
MYOC — FZD1 ・ WNT1 — FZD1 ・ WNT3A — FZD1 ・ WNT3 — FZD1 ・ WNT5A — FZD1 ・ WNT7B — FZD1 ・ WNT10A — FZD1 ・ WNT7A — FZD1 ・ WNT4 — FZD1 ・ WNT5B — FZD1 ・ WNT9A — FZD1
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