CDB15:0001572 WNT1 — FZD1

Experimentally validated in Mouse; Orthology-inferred in Human, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

A Wnt1 regulated Frizzled-1/β-Catenin signaling pathway as a candidate regulatory circuit controlling mesencephalic dopaminergic neuron-astrocyte crosstalk: Therapeutical relevance for neuron survival and neuroprotection.

Molecular neurodegeneration, 2011; PubMed, Mus Musculus Wnt1 — Mus Musculus Fzd1

ABSTRACT: Dopamine-synthesizing (dopaminergic, DA) neurons in the ventral midbrain (VM) constitute a pivotal neuronal population controlling motor behaviors, cognitive and affective brain functions, which generation critically relies on the activation of Wingless-type MMTV integration site (Wnt)/β-catenin pathway in their progenitors. In Parkinson's disease, DA cell bodies within the substantia nigra pars compacta (SNpc) progressively degenerate, with causes and mechanisms poorly understood. Emerging evidence suggests that Wnt signaling via Frizzled (Fzd) receptors may play a role in different degenerative states, but little is known about Wnt signaling in the adult midbrain. Using in vitro and in vivo model systems of DA degeneration, along with functional studies in both intact and SN lesioned mice, we herein highlight an intrinsic Wnt1/Fzd-1/β-catenin tone critically contributing to the survival and protection of adult midbrain DA neurons.

Basic Information on WNT1

Ligand Name: Wnt family member 1

Other Symbols: INT1

Ligand Location: secreted based on perplexity, uniprot

HGNC Gene Symbol Report: WNT1

GeneCards: WNT1

HGNC Gene Group: Receptor ligands: Wnt family

Functional Annotations for WNT1

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for WNT1

WNT1 — FZD3 ・ WNT1 — FZD5 ・ WNT1 — FZD7 ・ WNT1 — FZD8 ・ WNT1 — LRP5 ・ WNT1 — LRP6 ・ WNT1 — RYK ・ WNT1 — FZD10 ・ WNT1 — FZD2 ・ WNT1 — FZD4 ・ WNT1 — ROR2 ・ WNT1 — FZD6

Basic Information on FZD1

Receptor Name: frizzled class receptor 1

Other Symbols: DKFZp564G072, Hfz1

Receptor Location: cell membrane based on hpa, perplexity, uniprot

HGNC Gene Symbol Report: FZD1

GeneCards: FZD1

HGNC Gene Group: 7TM proteins

Functional Annotations for FZD1

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for FZD1

MYOC — FZD1 ・ WNT2 — FZD1 ・ WNT3A — FZD1 ・ WNT3 — FZD1 ・ WNT5A — FZD1 ・ WNT7B — FZD1 ・ WNT10A — FZD1 ・ WNT7A — FZD1 ・ WNT4 — FZD1 ・ WNT5B — FZD1 ・ WNT9A — FZD1