CDB20:0002961 WNT1 — FZD10

Experimentally validated in Chicken; Orthology-inferred in Human, Mouse, Rat, Frog, Zebrafish, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

Frizzled10 mediates WNT1 and WNT3A signaling in the dorsal spinal cord of the developing chick embryo.

Developmental dynamics : an official publication of the American Association of Anatomists, 2014; PubMed, Gallus gallus WNT1 — Gallus gallus FZD10

ABSTRACT: WNT1 and WNT3A drive a dorsal to ventral gradient of β-catenin-dependent Wnt signaling in the developing spinal cord. However, the identity of the receptors mediating downstream functions remains poorly understood.

Basic Information on WNT1

Ligand Name: Wnt family member 1

Other Symbols: INT1

Ligand Location: secreted based on perplexity, uniprot

HGNC Gene Symbol Report: WNT1

GeneCards: WNT1

HGNC Gene Group: Receptor ligands: Wnt family

Functional Annotations for WNT1

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for WNT1

WNT1 — FZD1 ・ WNT1 — FZD3 ・ WNT1 — FZD5 ・ WNT1 — FZD7 ・ WNT1 — FZD8 ・ WNT1 — LRP5 ・ WNT1 — LRP6 ・ WNT1 — RYK ・ WNT1 — FZD2 ・ WNT1 — FZD4 ・ WNT1 — ROR2 ・ WNT1 — FZD6

Basic Information on FZD10

Receptor Name: frizzled class receptor 10

Other Symbols: CD350

Receptor Location: cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: FZD10

GeneCards: FZD10

HGNC Gene Group: 7TM proteins, CD molecules

Functional Annotations for FZD10

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for FZD10

MYOC — FZD10 ・ WNT7A — FZD10 ・ WNT7B — FZD10 ・ WNT3A — FZD10 ・ WNT9A — FZD10 ・ WNT9B — FZD10 ・ WNT10A — FZD10 ・ WNT11 — FZD10 ・ WNT3 — FZD10