CDB15:0001573 WNT1 — FZD3

Experimentally validated in Mouse; Orthology-inferred in Human, Rat, Frog, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

Ryk-mediated Wnt repulsion regulates posterior-directed growth of corticospinal tract.

Nature neuroscience, 2005; PubMed, Mus Musculus Wnt1 — Mus Musculus Fzd3

ABSTRACT: Guidance cues along the longitudinal axis of the CNS are poorly understood. Wnt proteins attract ascending somatosensory axons to project from the spinal cord to the brain. Here we show that Wnt proteins repel corticospinal tract (CST) axons in the opposite direction. Several Wnt genes were found to be expressed in the mouse spinal cord gray matter, cupping the dorsal funiculus, in an anterior-to-posterior decreasing gradient along the cervical and thoracic cord. Wnts repelled CST axons in collagen gel assays through a conserved high-affinity receptor, Ryk, which is expressed in CST axons. Neonatal spinal cord secretes diffusible repellent(s) in an anterior-posterior graded fashion, with anterior cord being stronger, and the repulsive activity was blocked by antibodies to Ryk (anti-Ryk). Intrathecal injection of anti-Ryk blocked the posterior growth of CST axons. Therefore, Wnt proteins may have a general role in anterior-posterior guidance of multiple classes of axons.

Basic Information on WNT1

Ligand Name: Wnt family member 1

Other Symbols: INT1

Ligand Location: secreted based on perplexity, uniprot

HGNC Gene Symbol Report: WNT1

GeneCards: WNT1

HGNC Gene Group: Receptor ligands: Wnt family

Functional Annotations for WNT1

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for WNT1

WNT1 — FZD1 ・ WNT1 — FZD5 ・ WNT1 — FZD7 ・ WNT1 — FZD8 ・ WNT1 — LRP5 ・ WNT1 — LRP6 ・ WNT1 — RYK ・ WNT1 — FZD10 ・ WNT1 — FZD2 ・ WNT1 — FZD4 ・ WNT1 — ROR2 ・ WNT1 — FZD6

Basic Information on FZD3

Receptor Name: frizzled class receptor 3

Other Symbols: Fz-3

Receptor Location: cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: FZD3

GeneCards: FZD3

HGNC Gene Group: 7TM proteins

Functional Annotations for FZD3

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for FZD3

CTHRC1 — FZD3 ・ MYOC — FZD3 ・ WNT5A — FZD3 ・ TSKU — FZD3 ・ WNT2B — FZD3 ・ WNT3A — FZD3