CDB15:0000075 APOE — LRP5

Experimentally validated in Human; Orthology-inferred in Mouse, Rat, Frog, Zebrafish, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

A new low density lipoprotein receptor related protein, LRP5, is expressed in hepatocytes and adrenal cortex, and recognizes apolipoprotein E.

Journal of biochemistry, 1998; PubMed, Homo sapiens APOE — Homo sapiens LRP5

ABSTRACT: The isolation and characterization of rabbit and human cDNAs revealed a new low density lipoprotein receptor (LDLR)-related protein (LRP) designated as LRP5. Human LRP5 cDNA encodes a 1, 616-amino acid type I membrane-like protein with three ligand binding repeats in its extracellular region. LDLR-deficient cells transduced by recombinant adenovirus containing human LRP5 exhibited increased binding of apolipoprotein E (apoE)-enriched beta-migrating very low density lipoprotein. Northern blotting and in situ hybridization revealed a high level of LRP5 expression in hepatocytes and the adrenal gland cortex. In LDLR-deficient Watanabe heritable hyperlipidemic rabbits, LRP5 mRNA was increased in the liver and accumulated in cholesterol-laden foam cells of atherosclerotic lesions.

Basic Information on APOE

Ligand Name: apolipoprotein E

Other Symbols: AD2

Ligand Location: secreted based on hpa, perplexity, uniprot

HGNC Gene Symbol Report: APOE

GeneCards: APOE

HGNC Gene Group: Apolipoproteins

Functional Annotations for APOE

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for APOE

APOE — LDLR ・ APOE — LRP1 ・ APOE — LRP2 ・ APOE — LRP8 ・ APOE — SCARB1 ・ APOE — SORL1 ・ APOE — VLDLR ・ APOE — ABCA1 ・ APOE — LILRB3 ・ APOE — LILRB4 ・ APOE — LRP4 ・ APOE — LSR ・ APOE — TREM2

Basic Information on LRP5

Receptor Name: LDL receptor related protein 5

Other Symbols: LRP7, OPPG, EVR1, LR3, BMND1, HBM, OPS, OPTA1, VBCH2, EVR4

Receptor Location: cell membrane based on perplexity

HGNC Gene Symbol Report: LRP5

GeneCards: LRP5

HGNC Gene Group: Low density lipoprotein receptors

Functional Annotations for LRP5

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for LRP5

DKK1 — LRP5 ・ SOST — LRP5 ・ WNT1 — LRP5 ・ WNT5A — LRP5 ・ WNT7B — LRP5 ・ WNT16 — LRP5 ・ SELENOP — LRP5 ・ TGM2 — LRP5 ・ WNT10B — LRP5 ・ WNT2 — LRP5 ・ WNT3 — LRP5 ・ WNT3A — LRP5 ・ WNT4 — LRP5 ・ WNT7A — LRP5 ・ WNT9A — LRP5 ・ WNT9B — LRP5