CDB15:0001592 WNT3A — RYK

Experimentally validated in Mouse; Orthology-inferred in Human, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth.

Cell, 2004; PubMed, Mus Musculus Wnt3a — Mus Musculus Ryk
ABSTRACT: The Ryk receptor belongs to the atypical receptor tyrosine kinase family. It is a new member of the family of Wnt receptor proteins. However, the molecular mechanisms by which the Ryk receptor functions remain unknown. Here, we report that mammalian Ryk, unlike the Drosophila Ryk homolog Derailed, functions as a coreceptor along with Frizzled for Wnt ligands. Ryk also binds to Dishevelled, through which it activates the canonical Wnt pathway, providing a link between Wnt and Dishevelled. Transgenic mice expressing Ryk siRNA exhibit defects in axon guidance, and Ryk is required for neurite outgrowth induced by Wnt-3a and in the activation of T cell factor (TCF) induced by Wnt-1. Thus, Ryk appears to play a crucial role in Wnt-mediated signaling.
Basic Information on WNT3A
Ligand Name: Wnt family member 3A
Other Symbols: N/A
Ligand Location: secreted based on hpa, perplexity, uniprot
HGNC Gene Symbol Report: WNT3A
GeneCards: WNT3A
Functional Annotations for WNT3A
Gene Ontologies: PAN-GO, AmiGO 2
Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)
Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)
Interactions with other Receptors for WNT3A
WNT3A — FZD1 ・ WNT3A — FZD2 ・ WNT3A — FZD5 ・ WNT3A — FZD6 ・ WNT3A — FZD7 ・ WNT3A — FZD8 ・ WNT3A — LRP6 ・ WNT3A — FZD10 ・ WNT3A — APP ・ WNT3A — FZD3 ・ WNT3A — FZD4 ・ WNT3A — GPC3 ・ WNT3A — GPC5 ・ WNT3A — LGR5 ・ WNT3A — LRP5 ・ WNT3A — PTK7
Basic Information on RYK
Receptor Name: receptor like tyrosine kinase
Other Symbols: JTK5A, D3S3195, RYK1, JTK5
Receptor Location: cell membrane based on perplexity
HGNC Gene Symbol Report: RYK
GeneCards: RYK
HGNC Gene Group: Receptor kinases
Functional Annotations for RYK
Gene Ontologies: PAN-GO, AmiGO 2
Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)
Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)
Interactions with other Ligands for RYK
WNT1 — RYK ・ WNT3 — RYK ・ WNT5A — RYK
← CDB15 WNT3A LRP6
CDB15 WNT3 FZD1 →