CDB25:0004537 WNT9A — MUSK

Experimentally validated in Mouse; Orthology-inferred in Human, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

Wnt proteins regulate acetylcholine receptor clustering in muscle cells.

Molecular brain, 2012; PubMed, Mus Musculus Wnt9a — Mus Musculus Musk

ABSTRACT: The neuromuscular junction (NMJ) is a cholinergic synapse that rapidly conveys signals from motoneurons to muscle cells and exhibits a high degree of subcellular specialization characteristic of chemical synapses. NMJ formation requires agrin and its coreceptors LRP4 and MuSK. Increasing evidence indicates that Wnt signaling regulates NMJ formation in Drosophila, C. elegans and zebrafish.

Basic Information on WNT9A

Ligand Name: Wnt family member 9A

Other Symbols: WNT14

Ligand Location: secreted based on perplexity, uniprot

HGNC Gene Symbol Report: WNT9A

GeneCards: WNT9A

HGNC Gene Group: MicroRNA host genes, Receptor ligands: Wnt family

Functional Annotations for WNT9A

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for WNT9A

WNT9A — FZD10 ・ WNT9A — FZD4 ・ WNT9A — EGFR ・ WNT9A — FZD1 ・ WNT9A — FZD5 ・ WNT9A — FZD8 ・ WNT9A — FZD9 ・ WNT9A — LRP5 ・ WNT9A — LRP6

Basic Information on MUSK

Receptor Name: muscle associated receptor tyrosine kinase

Other Symbols: N/A

Receptor Location: cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: MUSK

GeneCards: MUSK

HGNC Gene Group: Receptor kinases, Immunoglobulin superfamily domain containing

Functional Annotations for MUSK

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for MUSK

AGRN — MUSK ・ COLQ — MUSK ・ BMP4 — MUSK ・ WNT11 — MUSK