CDB25:0004468 WNT11 — MUSK

Experimentally validated in Mouse; Orthology-inferred in Human, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

Wnt proteins regulate acetylcholine receptor clustering in muscle cells.

Molecular brain, 2012; PubMed, Mus Musculus Wnt11 — Mus Musculus Musk
ABSTRACT: The neuromuscular junction (NMJ) is a cholinergic synapse that rapidly conveys signals from motoneurons to muscle cells and exhibits a high degree of subcellular specialization characteristic of chemical synapses. NMJ formation requires agrin and its coreceptors LRP4 and MuSK. Increasing evidence indicates that Wnt signaling regulates NMJ formation in Drosophila, C. elegans and zebrafish.
Basic Information on WNT11
Ligand Name: Wnt family member 11
Other Symbols: N/A
Ligand Location: secreted based on perplexity, uniprot
HGNC Gene Symbol Report: WNT11
GeneCards: WNT11
Functional Annotations for WNT11
Gene Ontologies: PAN-GO, AmiGO 2
Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)
Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)
Interactions with other Receptors for WNT11
WNT11 — FZD7 ・ WNT11 — FZD8 ・ WNT11 — FZD10 ・ WNT11 — FZD2 ・ WNT11 — FZD5 ・ WNT11 — FZD6 ・ WNT11 — ROR2
Basic Information on MUSK
Receptor Name: muscle associated receptor tyrosine kinase
Other Symbols: N/A
Receptor Location: cell membrane based on perplexity, uniprot
HGNC Gene Symbol Report: MUSK
GeneCards: MUSK
Functional Annotations for MUSK
Gene Ontologies: PAN-GO, AmiGO 2
Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)
Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)
Interactions with other Ligands for MUSK
AGRN — MUSK ・ COLQ — MUSK ・ BMP4 — MUSK ・ WNT9A — MUSK
← CDB25 WNT11 FZD6
CDB25 WNT11 ROR2 →