CDB20:0002969 WNT11 — FZD8

Experimentally validated in Human; Orthology-inferred in Mouse, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

Frizzled-8 integrates Wnt-11 and transforming growth factor-β signaling in prostate cancer.

Nature communications, 2018; PubMed, Homo sapiens WNT11 — Homo sapiens FZD8

ABSTRACT: Wnt-11 promotes cancer cell migration and invasion independently of β-catenin but the receptors involved remain unknown. Here, we provide evidence that FZD8 is a major Wnt-11 receptor in prostate cancer that integrates Wnt-11 and TGF-β signals to promote EMT. FZD8 mRNA is upregulated in multiple prostate cancer datasets and in metastatic cancer cell lines in vitro and in vivo. Analysis of patient samples reveals increased levels of FZD8 in cancer, correlating with Wnt-11. FZD8 co-localizes and co-immunoprecipitates with Wnt-11 and potentiates Wnt-11 activation of ATF2-dependent transcription. FZD8 silencing reduces prostate cancer cell migration, invasion, three-dimensional (3D) organotypic cell growth, expression of EMT-related genes, and TGF-β/Smad-dependent signaling. Mechanistically, FZD8 forms a TGF-β-regulated complex with TGF-β receptors that is mediated by the extracellular domains of FZD8 and TGFBR1. Targeting FZD8 may therefore inhibit aberrant activation of both Wnt and TGF-β signals in prostate cancer.

Basic Information on WNT11

Ligand Name: Wnt family member 11

Other Symbols: N/A

Ligand Location: secreted based on perplexity, uniprot

HGNC Gene Symbol Report: WNT11

GeneCards: WNT11

HGNC Gene Group: Receptor ligands: Wnt family

Functional Annotations for WNT11

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for WNT11

WNT11 — FZD7 ・ WNT11 — FZD10 ・ WNT11 — FZD2 ・ WNT11 — FZD5 ・ WNT11 — FZD6 ・ WNT11 — MUSK ・ WNT11 — ROR2

Basic Information on FZD8

Receptor Name: frizzled class receptor 8

Other Symbols: FZ-8

Receptor Location: cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: FZD8

GeneCards: FZD8

HGNC Gene Group: MicroRNA host genes, 7TM proteins

Functional Annotations for FZD8

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for FZD8

IGFBP4 — FZD8 ・ RSPO1 — FZD8 ・ RSPO3 — FZD8 ・ WNT1 — FZD8 ・ WNT2 — FZD8 ・ WNT3A — FZD8 ・ WNT3 — FZD8 ・ WNT5A — FZD8 ・ WNT10A — FZD8 ・ WNT5B — FZD8 ・ WNT7B — FZD8 ・ WNT8A — FZD8 ・ WNT9B — FZD8 ・ WNT2B — FZD8 ・ WNT4 — FZD8 ・ WNT7A — FZD8 ・ WNT9A — FZD8