CDB25:0004469 WNT11 — ROR2

Experimentally validated in Human; Orthology-inferred in Mouse, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

WNT11/ROR2 signaling is associated with tumor invasion and poor survival in breast cancer.

Journal of experimental & clinical cancer research : CR, 2021; PubMed, Homo sapiens WNT11 — Homo sapiens ROR2
ABSTRACT: Breast cancer has been associated with activation of the WNT signaling pathway, although no driver mutations in WNT genes have been found yet. Instead, a high expression of the alternative WNT receptor ROR2 was observed, in particular in breast cancer brain metastases. However, its respective ligand and downstream signaling in this context remained unknown.
Basic Information on WNT11
Ligand Name: Wnt family member 11
Other Symbols: N/A
Ligand Location: secreted based on perplexity, uniprot
HGNC Gene Symbol Report: WNT11
GeneCards: WNT11
Functional Annotations for WNT11
Gene Ontologies: PAN-GO, AmiGO 2
Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)
Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)
Interactions with other Receptors for WNT11
WNT11 — FZD7 ・ WNT11 — FZD8 ・ WNT11 — FZD10 ・ WNT11 — FZD2 ・ WNT11 — FZD5 ・ WNT11 — FZD6 ・ WNT11 — MUSK
Basic Information on ROR2
Receptor Name: receptor tyrosine kinase like orphan receptor 2
Other Symbols: NTRKR2, BDB, BDB1
Receptor Location: cell membrane based on perplexity, uniprot
HGNC Gene Symbol Report: ROR2
GeneCards: ROR2
Functional Annotations for ROR2
Gene Ontologies: PAN-GO, AmiGO 2
Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)
Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)
Interactions with other Ligands for ROR2
GDF5 — ROR2 ・ WNT5A — ROR2 ・ CTHRC1 — ROR2 ・ WNT1 — ROR2 ・ WNT2B — ROR2 ・ WNT3 — ROR2 ・ WNT5B — ROR2 ・ WNT8A — ROR2
← CDB25 WNT11 MUSK
CDB25 WNT2 FZD6 →