CDB20:0002874 PRG4 — TLR2

Experimentally validated in Human; Orthology-inferred in Mouse, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

The interaction of lubricin/proteoglycan 4 (PRG4) with toll-like receptors 2 and 4: an anti-inflammatory role of PRG4 in synovial fluid.

Arthritis research & therapy, 2015; PubMed, Homo sapiens PRG4 — Homo sapiens TLR2

ABSTRACT: Lubricin/proteoglycan-4 (PRG4) is a mucinous glycoprotein secreted by synovial fibroblasts and superficial zone chondrocytes. PRG4 has a homeostatic multifaceted role in the joint. PRG4 intra-articular treatment retards progression of cartilage degeneration in pre-clinical posttraumatic osteoarthritis models. The objective of this study is to evaluate the binding of recombinant human PRG4 (rhPRG4) and native human PRG4 (nhPRG4) to toll-like receptors 2 and 4 (TLR2 and TLR4) and whether this interaction underpins a PRG4 anti-inflammatory role in synovial fluid (SF) from patients with osteoarthritis (OA) and rheumatoid arthritis (RA).

Basic Information on PRG4

Ligand Name: proteoglycan 4

Other Symbols: CACP, JCAP, SZP, MSF, HAPO, bG174L6.2, FLJ32635

Ligand Location: secreted based on perplexity, uniprot

HGNC Gene Symbol Report: PRG4

GeneCards: PRG4

HGNC Gene Group: unknown

Functional Annotations for PRG4

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for PRG4

PRG4 — TLR4 ・ PRG4 — CD44

Basic Information on TLR2

Receptor Name: toll like receptor 2

Other Symbols: TIL4, CD282

Receptor Location: cell membrane based on hpa, perplexity

HGNC Gene Symbol Report: TLR2

GeneCards: TLR2

HGNC Gene Group: TIR domain containing, CD molecules

Functional Annotations for TLR2

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for TLR2

BGN — TLR2 ・ HSP90B1 — TLR2 ・ RNASE2 — TLR2 ・ SFTPA1 — TLR2 ・ VCAN — TLR2 ・ ZG16B — TLR2 ・ ANXA2 — TLR2 ・ DCN — TLR2 ・ CCN1 — TLR2 ・ HMGB1 — TLR2 ・ HSPA1A — TLR2 ・ S100A8 — TLR2 ・ SAA1 — TLR2 ・ SFTPA2 — TLR2 ・ SFTPD — TLR2 ・ WNT5A — TLR2