CDB20:0002587 ANXA2 — TLR2

Experimentally validated in Mouse; Orthology-inferred in Human, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

Monomeric annexin A2 is an oxygen-regulated toll-like receptor 2 ligand and adjuvant.

Journal for immunotherapy of cancer, 2016; PubMed, Mus Musculus Anxa2 — Mus Musculus Tlr2

ABSTRACT: Annexin A2 (ANXA2) is a pleiotropic, calcium-dependent, phospholipid-binding protein with a broad tissue distribution. It can be intracellular, membrane-bound, or secreted, and it exists as a monomer or heterotetramer. The secreted ANXA2 heterotetramer signals human and murine macrophages to produce IL-1, IL-6, and TNF-α through TLR4/MyD88- and TRIF-dependent pathways.

Basic Information on ANXA2

Ligand Name: annexin A2

Other Symbols: ANX2, ANX2L4, CAL1H, LPC2D, LIP2

Ligand Location: secreted based on hpa, perplexity, uniprot, cell membrane based on hpa, perplexity

HGNC Gene Symbol Report: ANXA2

GeneCards: ANXA2

HGNC Gene Group: Annexins

Functional Annotations for ANXA2

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for ANXA2

ANXA2 — ROBO4 ・ ANXA2 — TLR4

Basic Information on TLR2

Receptor Name: toll like receptor 2

Other Symbols: TIL4, CD282

Receptor Location: cell membrane based on hpa, perplexity

HGNC Gene Symbol Report: TLR2

GeneCards: TLR2

HGNC Gene Group: TIR domain containing, CD molecules

Functional Annotations for TLR2

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for TLR2

BGN — TLR2 ・ HSP90B1 — TLR2 ・ RNASE2 — TLR2 ・ SFTPA1 — TLR2 ・ VCAN — TLR2 ・ ZG16B — TLR2 ・ DCN — TLR2 ・ PRG4 — TLR2 ・ CCN1 — TLR2 ・ HMGB1 — TLR2 ・ HSPA1A — TLR2 ・ S100A8 — TLR2 ・ SAA1 — TLR2 ・ SFTPA2 — TLR2 ・ SFTPD — TLR2 ・ WNT5A — TLR2