CDB25:0003732 HMGB1 — TLR2

Experimentally validated in Mouse; Orthology-inferred in Human, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

HMGB1 mediates endogenous TLR2 activation and brain tumor regression.

PLoS medicine, 2009; PubMed, Mus Musculus Hmgb1 — Mus Musculus Tlr2

ABSTRACT: Glioblastoma multiforme (GBM) is the most aggressive primary brain tumor that carries a 5-y survival rate of 5%. Attempts at eliciting a clinically relevant anti-GBM immune response in brain tumor patients have met with limited success, which is due to brain immune privilege, tumor immune evasion, and a paucity of dendritic cells (DCs) within the central nervous system. Herein we uncovered a novel pathway for the activation of an effective anti-GBM immune response mediated by high-mobility-group box 1 (HMGB1), an alarmin protein released from dying tumor cells, which acts as an endogenous ligand for Toll-like receptor 2 (TLR2) signaling on bone marrow-derived GBM-infiltrating DCs.

Basic Information on HMGB1

Ligand Name: high mobility group box 1

Other Symbols: HMG1, HMG3, SBP-1, DKFZp686A04236

Ligand Location: secreted based on hpa, perplexity, uniprot, cell membrane based on uniprot

HGNC Gene Symbol Report: HMGB1

GeneCards: HMGB1

HGNC Gene Group: High mobility group

Functional Annotations for HMGB1

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for HMGB1

HMGB1 — SDC1 ・ HMGB1 — HAVCR2 ・ HMGB1 — AGER ・ HMGB1 — CXCR4 ・ HMGB1 — ITGAV ・ HMGB1 — ITGB3 ・ HMGB1 — LRP1 ・ HMGB1 — LY96 ・ HMGB1 — TLR4 ・ HMGB1 — TREM1 ・ HMGB1 — SCARA5

Basic Information on TLR2

Receptor Name: toll like receptor 2

Other Symbols: TIL4, CD282

Receptor Location: cell membrane based on hpa, perplexity

HGNC Gene Symbol Report: TLR2

GeneCards: TLR2

HGNC Gene Group: TIR domain containing, CD molecules

Functional Annotations for TLR2

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for TLR2

BGN — TLR2 ・ HSP90B1 — TLR2 ・ RNASE2 — TLR2 ・ SFTPA1 — TLR2 ・ VCAN — TLR2 ・ ZG16B — TLR2 ・ ANXA2 — TLR2 ・ DCN — TLR2 ・ PRG4 — TLR2 ・ CCN1 — TLR2 ・ HSPA1A — TLR2 ・ S100A8 — TLR2 ・ SAA1 — TLR2 ・ SFTPA2 — TLR2 ・ SFTPD — TLR2 ・ WNT5A — TLR2