CDB25:0003734 HMGB1 — TREM1

Experimentally validated in Human; Orthology-inferred in Mouse, Rat, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

The Interaction of HMGB1 with the Proinflammatory TREM-1 Receptor Generates Cytotoxic Lymphocytes Active against HLA-Negative Tumor Cells.

International journal of molecular sciences, 2024; PubMed, Homo sapiens HMGB1 — Homo sapiens TREM1

ABSTRACT: High mobility group protein (HMGB1) is secreted by myeloid cells and cells of damaged tissues during inflammation, causing inflammatory reactions through various receptors, including TLRS and RAGE. TREM-1 is considered to be one of the potential HMGB1 receptors. In this work, we have shown that the HMGB1 protein is able to bind to the TREM-1 receptor at high affinity both in solution and on the cell surface. This binding causes lymphocytes to release cytokines IL-2, IL-1b, IL-6, TNF and Ifny into the medium, which leads to the appearance of cytotoxic lymphocytes in PBMC capable of lysing HLA-negative tumor cells. Expanding the spectra of proinflammatory receptor ligands and understanding the mechanisms of their action is essential for the creation of new immunotherapy pathways.

Basic Information on HMGB1

Ligand Name: high mobility group box 1

Other Symbols: HMG1, HMG3, SBP-1, DKFZp686A04236

Ligand Location: secreted based on hpa, perplexity, uniprot, cell membrane based on uniprot

HGNC Gene Symbol Report: HMGB1

GeneCards: HMGB1

HGNC Gene Group: High mobility group

Functional Annotations for HMGB1

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for HMGB1

HMGB1 — SDC1 ・ HMGB1 — HAVCR2 ・ HMGB1 — AGER ・ HMGB1 — CXCR4 ・ HMGB1 — ITGAV ・ HMGB1 — ITGB3 ・ HMGB1 — LRP1 ・ HMGB1 — LY96 ・ HMGB1 — TLR2 ・ HMGB1 — TLR4 ・ HMGB1 — SCARA5

Basic Information on TREM1

Receptor Name: triggering receptor expressed on myeloid cells 1

Other Symbols: TREM-1, CD354

Receptor Location: cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: TREM1

GeneCards: TREM1

HGNC Gene Group: CD molecules, Immunoglobulin superfamily domain containing

Functional Annotations for TREM1

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for TREM1

CIRBP — TREM1 ・ PGLYRP1 — TREM1