CDB25:0003745 HSPA1A — TLR2

Experimentally validated in Human; Orthology-inferred in Rat, Frog, Zebrafish, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

The interaction of HspA1A with TLR2 and TLR4 in the response of neutrophils induced by ovarian cancer cells in vitro.

Cell stress & chaperones, 2012; PubMed, Homo sapiens HSPA1A — Homo sapiens TLR2

ABSTRACT: Inducible heat shock protein (HspA1A) promotes tumor cell growth and survival. It also interacts with effector cells of the innate immune system and affects their activity. Recently, we showed that the direct contact of ovarian cancer cells, isolated from tumor specimens, with neutrophils intensified their biological functions. Our current experiments demonstrate that the activation of neutrophils, followed by an increased production of reactive oxygen species, by cancer cells involves the interaction of HspA1A from cancer cells with Toll-like receptors 2 and 4 expressed on the neutrophils' surface. Our data may have a practical implication for targeted anticancer therapies based, among other factors, on the inhibition of HspA1A expression in the cancer cells.

Basic Information on HSPA1A

Ligand Name: heat shock protein family A (Hsp70) member 1A

Other Symbols: HSPA1, HSP70-1

Ligand Location: secreted based on uniprot

HGNC Gene Symbol Report: HSPA1A

GeneCards: HSPA1A

HGNC Gene Group: TIM23 complex, Heat shock proteins

Functional Annotations for HSPA1A

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for HSPA1A

HSPA1A — TLR4 ・ HSPA1A — LRP1

Basic Information on TLR2

Receptor Name: toll like receptor 2

Other Symbols: TIL4, CD282

Receptor Location: cell membrane based on hpa, perplexity

HGNC Gene Symbol Report: TLR2

GeneCards: TLR2

HGNC Gene Group: TIR domain containing, CD molecules

Functional Annotations for TLR2

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for TLR2

BGN — TLR2 ・ HSP90B1 — TLR2 ・ RNASE2 — TLR2 ・ SFTPA1 — TLR2 ・ VCAN — TLR2 ・ ZG16B — TLR2 ・ ANXA2 — TLR2 ・ DCN — TLR2 ・ PRG4 — TLR2 ・ CCN1 — TLR2 ・ HMGB1 — TLR2 ・ S100A8 — TLR2 ・ SAA1 — TLR2 ・ SFTPA2 — TLR2 ・ SFTPD — TLR2 ・ WNT5A — TLR2