CDB25:0004123 PRG4 — CD44

Experimentally validated in Human; Orthology-inferred in Mouse, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

Lubricin/Proteoglycan 4 Binding to CD44 Receptor: A Mechanism of the Suppression of Proinflammatory Cytokine-Induced Synoviocyte Proliferation by Lubricin.

Arthritis & rheumatology, 2015; PubMed, Homo sapiens PRG4 — Homo sapiens CD44

ABSTRACT: To evaluate the binding of recombinant human proteoglycan 4 (rhPRG4) to CD44 receptor and its consequences on cytokine-induced synoviocyte proliferation.

Basic Information on PRG4

Ligand Name: proteoglycan 4

Other Symbols: CACP, JCAP, SZP, MSF, HAPO, bG174L6.2, FLJ32635

Ligand Location: secreted based on perplexity, uniprot

HGNC Gene Symbol Report: PRG4

GeneCards: PRG4

HGNC Gene Group: unknown

Functional Annotations for PRG4

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for PRG4

PRG4 — TLR2 ・ PRG4 — TLR4

Basic Information on CD44

Receptor Name: CD44 molecule (IN blood group)

Other Symbols: MIC4, MDU2, MDU3, IN, MC56, Pgp1, PGP-1, CD44R, HCELL, CSPG8, Hermes-1, CDw44, HUTCH-1, HUTCH-I, ECM-III, H-CAM

Receptor Location: cell membrane based on hpa, perplexity, uniprot

HGNC Gene Symbol Report: CD44

GeneCards: CD44

HGNC Gene Group: Blood group antigens, CD molecules, Proteoglycans

Functional Annotations for CD44

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for CD44

COL14A1 — CD44 ・ COL1A1 — CD44 ・ COL1A2 — CD44 ・ FGF1 — CD44 ・ FGF2 — CD44 ・ FN1 — CD44 ・ HBEGF — CD44 ・ HGF — CD44 ・ MADCAM1 — CD44 ・ MMP7 — CD44 ・ MMP9 — CD44 ・ SPP1 — CD44 ・ VCAN — CD44 ・ VIM — CD44 ・ LGALS9 — CD44 ・ SELE — CD44 ・ BGN — CD44 ・ C1QA — CD44 ・ C1QB — CD44 ・ C1QC — CD44 ・ CD6 — CD44 ・ DMP1 — CD44 ・ GPNMB — CD44 ・ LAMA5 — CD44 ・ SIGLEC15 — CD44 ・ VEGFA — CD44