CDB15:0001077 MMP9 — CD44

Experimentally validated in Mouse; Orthology-inferred in Human, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis.

Genes & development, 2000; PubMed, Mus Musculus Mmp9 — Mus Musculus Cd44

ABSTRACT: We have uncovered a novel functional relationship between the hyaluronan receptor CD44, the matrix metalloproteinase-9 (MMP-9) and the multifunctional cytokine TGF-beta in the control of tumor-associated tissue remodeling. CD44 provides a cell surface docking receptor for proteolytically active MMP-9 and we show here that localization of MMP-9 to cell surface is required for its ability to promote tumor invasion and angiogenesis. Our observations also indicate that MMP-9, as well as MMP-2, proteolytically cleaves latent TGF-beta, providing a novel and potentially important mechanism for TGF-beta activation. In addition, we show that MMP-9 localization to the surface of normal keratinocytes is CD44 dependent and can activate latent TGF-beta. These observations suggest that coordinated CD44, MMP-9, and TGF-beta function may provide a physiological mechanism of tissue remodeling that can be adopted by malignant cells to promote tumor growth and invasion.

Basic Information on MMP9

Ligand Name: matrix metallopeptidase 9

Other Symbols: CLG4B

Ligand Location: secreted based on hpa, perplexity, uniprot

HGNC Gene Symbol Report: MMP9

GeneCards: MMP9

HGNC Gene Group: Metallopeptidases

Functional Annotations for MMP9

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for MMP9

MMP9 — LRP1 ・ MMP9 — IFNAR1 ・ MMP9 — RECK ・ MMP9 — TLR4

Basic Information on CD44

Receptor Name: CD44 molecule (IN blood group)

Other Symbols: MIC4, MDU2, MDU3, IN, MC56, Pgp1, PGP-1, CD44R, HCELL, CSPG8, Hermes-1, CDw44, HUTCH-1, HUTCH-I, ECM-III, H-CAM

Receptor Location: cell membrane based on hpa, perplexity, uniprot

HGNC Gene Symbol Report: CD44

GeneCards: CD44

HGNC Gene Group: Blood group antigens, CD molecules, Proteoglycans

Functional Annotations for CD44

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for CD44

COL14A1 — CD44 ・ COL1A1 — CD44 ・ COL1A2 — CD44 ・ FGF1 — CD44 ・ FGF2 — CD44 ・ FN1 — CD44 ・ HBEGF — CD44 ・ HGF — CD44 ・ MADCAM1 — CD44 ・ MMP7 — CD44 ・ SPP1 — CD44 ・ VCAN — CD44 ・ VIM — CD44 ・ LGALS9 — CD44 ・ SELE — CD44 ・ BGN — CD44 ・ C1QA — CD44 ・ C1QB — CD44 ・ C1QC — CD44 ・ CD6 — CD44 ・ DMP1 — CD44 ・ GPNMB — CD44 ・ LAMA5 — CD44 ・ PRG4 — CD44 ・ SIGLEC15 — CD44 ・ VEGFA — CD44