CDB15:0001076 MMP7 — CD44

Experimentally validated in Human; Orthology-inferred in Mouse, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

CD44 anchors the assembly of matrilysin/MMP-7 with heparin-binding epidermal growth factor precursor and ErbB4 and regulates female reproductive organ remodeling.

Genes & development, 2002; PubMed, Homo sapiens MMP7 — Homo sapiens CD44

ABSTRACT: CD44 is a facultative proteoglycan implicated in cell adhesion and trafficking, as well as in tumor survival and progression. We demonstrate here that CD44 heparan sulfate proteoglycan (CD44HSPG) recruits proteolytically active matrix metalloproteinase 7 (matrilysin, MMP-7) and heparin-binding epidermal growth factor precursor (pro-HB-EGF) to form a complex on the surface of tumor cell lines, postpartum uterine and lactating mammary gland epithelium, and uterine smooth muscle. The HB-EGF precursor within this complex is processed by MMP-7, and the resulting mature HB-EGF engages and activates its receptor, ErbB4, leading to, among other events, cell survival. In CD44(-/-) mice, postpartum uterine involution is accelerated and maintenance of lactation is impaired. In both uterine and mammary epithelia of these mice, MMP-7 localization is altered and pro-HB-EGF processing as well as ErbB4 activation are decreased. Our observations provide a mechanism for the assembly and function of a cell surface complex composed of CD44HSPG, MMP 7, HB-EGF, and ErbB4 that may play an important role in the regulation of physiological tissue remodeling.

Basic Information on MMP7

Ligand Name: matrix metallopeptidase 7

Other Symbols: MPSL1, PUMP-1

Ligand Location: secreted based on hpa, perplexity, uniprot

HGNC Gene Symbol Report: MMP7

GeneCards: MMP7

HGNC Gene Group: Metallopeptidases

Functional Annotations for MMP7

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for MMP7

MMP7 — CD151

Basic Information on CD44

Receptor Name: CD44 molecule (IN blood group)

Other Symbols: MIC4, MDU2, MDU3, IN, MC56, Pgp1, PGP-1, CD44R, HCELL, CSPG8, Hermes-1, CDw44, HUTCH-1, HUTCH-I, ECM-III, H-CAM

Receptor Location: cell membrane based on hpa, perplexity, uniprot

HGNC Gene Symbol Report: CD44

GeneCards: CD44

HGNC Gene Group: Blood group antigens, CD molecules, Proteoglycans

Functional Annotations for CD44

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for CD44

COL14A1 — CD44 ・ COL1A1 — CD44 ・ COL1A2 — CD44 ・ FGF1 — CD44 ・ FGF2 — CD44 ・ FN1 — CD44 ・ HBEGF — CD44 ・ HGF — CD44 ・ MADCAM1 — CD44 ・ MMP9 — CD44 ・ SPP1 — CD44 ・ VCAN — CD44 ・ VIM — CD44 ・ LGALS9 — CD44 ・ SELE — CD44 ・ BGN — CD44 ・ C1QA — CD44 ・ C1QB — CD44 ・ C1QC — CD44 ・ CD6 — CD44 ・ DMP1 — CD44 ・ GPNMB — CD44 ・ LAMA5 — CD44 ・ PRG4 — CD44 ・ SIGLEC15 — CD44 ・ VEGFA — CD44