CDB15:0001466 THBS1 — ITGA4

Experimentally validated in Human; Orthology-inferred in Mouse, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

Alpha4beta1 integrin mediates selective endothelial cell responses to thrombospondins 1 and 2 in vitro and modulates angiogenesis in vivo.

Circulation research, 2004; PubMed, Homo sapiens THBS1 — Homo sapiens ITGA4

ABSTRACT: We examined the function of alpha4beta1 integrin in angiogenesis and in mediating endothelial cell responses to the angiogenesis modulators, thrombospondin-1 and thrombospondin-2. Alpha4beta1 supports adhesion of venous endothelial cells but not of microvascular endothelial cells on immobilized thrombospondin-1, vascular cell adhesion molecule-1, or recombinant N-terminal regions of thrombospondin-1 and thrombospondin-2. Chemotactic activities of this region of thrombospondin-1 and thrombospondin-2 are also mediated by alpha4beta1, whereas antagonism of fibroblast growth factor-2-stimulated chemotaxis is not mediated by this region. Immobilized N-terminal regions of thrombospondin-1 and thrombospondin-2 promote endothelial cell survival and proliferation in an alpha4beta1-dependent manner. Soluble alpha4beta1 antagonists inhibit angiogenesis in the chick chorioallantoic membrane and neovascularization of mouse muscle explants. The latter inhibition is thrombospondin-1-dependent and not observed in explants from thrombospondin-1-/- mice. Antagonizing alpha4beta1 may in part block proangiogenic activities of thrombospondin-1 and thrombospondin-2, because N-terminal regions of thrombospondin-1 and thrombospondin-2 containing the alpha4beta1 binding sequence stimulate angiogenesis in vivo. Therefore, alpha4beta1 is an important endothelial cell receptor for mediating motility and proliferative responses to thrombospondins and for modulation of angiogenesis.

Basic Information on THBS1

Ligand Name: thrombospondin 1

Other Symbols: TSP1, THBS, TSP, THBS-1, TSP-1

Ligand Location: secreted based on hpa, perplexity, uniprot, cell membrane based on hpa

HGNC Gene Symbol Report: THBS1

GeneCards: THBS1

HGNC Gene Group: Thrombospondin family

Functional Annotations for THBS1

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for THBS1

THBS1 — CD36 ・ THBS1 — CD47 ・ THBS1 — ITGA2B ・ THBS1 — ITGA3 ・ THBS1 — ITGA6 ・ THBS1 — ITGB1 ・ THBS1 — ITGB3 ・ THBS1 — LRP1 ・ THBS1 — SDC1 ・ THBS1 — SDC4 ・ THBS1 — PTPRJ ・ THBS1 — ITGA1 ・ THBS1 — ITGAV ・ THBS1 — SCARB2 ・ THBS1 — TGFBR1 ・ THBS1 — VLDLR

Basic Information on ITGA4

Receptor Name: integrin subunit alpha 4

Other Symbols: CD49D, CD49d

Receptor Location: cell membrane based on hpa, perplexity

HGNC Gene Symbol Report: ITGA4

GeneCards: ITGA4

HGNC Gene Group: CD molecules, Integrins

Functional Annotations for ITGA4

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for ITGA4

ADAM28 — ITGA4 ・ CD14 — ITGA4 ・ F13A1 — ITGA4 ・ FN1 — ITGA4 ・ ICAM4 — ITGA4 ・ MADCAM1 — ITGA4 ・ MDK — ITGA4 ・ SPP1 — ITGA4 ・ TGM2 — ITGA4 ・ THBS2 — ITGA4 ・ VCAM1 — ITGA4 ・ ADAM11 — ITGA4 ・ ADAM23 — ITGA4 ・ ADAM29 — ITGA4 ・ ADAM7 — ITGA4 ・ CXCL12 — ITGA4 ・ PLA2G2A — ITGA4 ・ SPON2 — ITGA4 ・ ADAM2 — ITGA4 ・ CD40LG — ITGA4 ・ CX3CL1 — ITGA4 ・ JAM2 — ITGA4 ・ MIA — ITGA4 ・ PLAUR — ITGA4 ・ SVEP1 — ITGA4 ・ VWF — ITGA4