CDB25:0004378 THBS1 — VLDLR

Experimentally validated in Mixed species; Orthology-inferred in Human, Mouse, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

Thrombospondin-1 binds to ApoER2 and VLDL receptor and functions in postnatal neuronal migration.

The EMBO journal, 2008; PubMed, Homo sapiens THBS1 — Mus Musculus Vldlr

ABSTRACT: Apolipoprotein E receptor 2 (ApoER2), very low-density lipoprotein receptor (VLDLR), and Dab1 are the main components of the Reelin signalling cascade. Reelin is the sole ligand defined so far in signalling through this pathway. Postnatal migration of neuronal precursors from the subventricular zone (SVZ) to the olfactory bulb (OB), however, depends on ApoER2 and Dab1, but functions independently of Reelin. Here, we show that thrombospondin-1 (THBS-1) is a novel physiological ligand for ApoER2 and VLDLR. THBS-1 is present in the SVZ and along the entire rostral migratory stream (RMS). It binds to ApoER2 and VLDLR and induces phosphorylation of Dab1. In contrast to Reelin, it does not induce Dab1 degradation or Akt phosphorylation, but stabilizes neuronal precursor chains derived from subventricular explants. Lack of THBS-1 results in anatomical abnormalities of the RMS and leads to a reduction of postnatal neuronal precursors entering the OB.

Basic Information on THBS1

Ligand Name: thrombospondin 1

Other Symbols: TSP1, THBS, TSP, THBS-1, TSP-1

Ligand Location: secreted based on hpa, perplexity, uniprot, cell membrane based on hpa

HGNC Gene Symbol Report: THBS1

GeneCards: THBS1

HGNC Gene Group: Thrombospondin family

Functional Annotations for THBS1

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for THBS1

THBS1 — CD36 ・ THBS1 — CD47 ・ THBS1 — ITGA2B ・ THBS1 — ITGA3 ・ THBS1 — ITGA4 ・ THBS1 — ITGA6 ・ THBS1 — ITGB1 ・ THBS1 — ITGB3 ・ THBS1 — LRP1 ・ THBS1 — SDC1 ・ THBS1 — SDC4 ・ THBS1 — PTPRJ ・ THBS1 — ITGA1 ・ THBS1 — ITGAV ・ THBS1 — SCARB2 ・ THBS1 — TGFBR1

Basic Information on VLDLR

Receptor Name: very low density lipoprotein receptor

Other Symbols: CARMQ1, CHRMQ1, VLDLRCH

Receptor Location: cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: VLDLR

GeneCards: VLDLR

HGNC Gene Group: Low density lipoprotein receptors

Functional Annotations for VLDLR

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for VLDLR

APOE — VLDLR ・ LPL — VLDLR ・ PLAU — VLDLR ・ RELN — VLDLR ・ TFPI — VLDLR ・ APOC1 — VLDLR ・ CLU — VLDLR ・ SERPINE1 — VLDLR