CDB15:0001405 SPP1 — ITGA4

Experimentally validated in Human; Orthology-inferred in Mouse, Rat, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

Thrombin-cleaved osteopontin regulates hemopoietic stem and progenitor cell functions through interactions with alpha9beta1 and alpha4beta1 integrins.

Blood, 2009; PubMed, Homo sapiens SPP1 — Homo sapiens ITGA4

ABSTRACT: Osteopontin (OPN), a multifunctional acidic glycoprotein, expressed by osteoblasts within the endosteal region of the bone marrow (BM) suppresses the proliferation of hemopoietic stem and progenitor cells and also regulates their lodgment within the BM after transplantation. Herein we demonstrate that OPN cleavage fragments are the most abundant forms of this protein within the BM. Studies aimed to determine how hemopoietic stem cells (HSCs) interact with OPN revealed for the first time that murine and human HSCs express alpha(9)beta(1) integrin. The N-terminal thrombin cleavage fragment of OPN through its binding to the alpha(9)beta(1) and alpha(4)beta(1) integrins plays a key role in the attraction, retention, regulation, and release of hemopoietic stem and progenitor cells to, in, and from their BM niche. Thrombin-cleaved OPN (trOPN) acts as a chemoattractant for stem and progenitor cells, mediating their migration in a manner that involves interaction with alpha(9)beta(1) and alpha(4)beta(1) integrins. In addition, in the absence of OPN, there is an increased number of white blood cells and, specifically, stem and progenitor cells in the peripheral circulation.

Basic Information on SPP1

Ligand Name: secreted phosphoprotein 1

Other Symbols: BNSP, OPN, BSPI, ETA-1, lnc-PKD2-2-3

Ligand Location: secreted based on hpa, perplexity, uniprot

HGNC Gene Symbol Report: SPP1

GeneCards: SPP1

HGNC Gene Group: Secretory calcium-binding phosphoprotein family, Receptor ligands

Functional Annotations for SPP1

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for SPP1

SPP1 — CD44 ・ SPP1 — ITGA5 ・ SPP1 — ITGA9 ・ SPP1 — ITGAV ・ SPP1 — ITGB1 ・ SPP1 — ITGB3 ・ SPP1 — ITGB5 ・ SPP1 — ITGA8 ・ SPP1 — ITGB6

Basic Information on ITGA4

Receptor Name: integrin subunit alpha 4

Other Symbols: CD49D, CD49d

Receptor Location: cell membrane based on hpa, perplexity

HGNC Gene Symbol Report: ITGA4

GeneCards: ITGA4

HGNC Gene Group: CD molecules, Integrins

Functional Annotations for ITGA4

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for ITGA4

ADAM28 — ITGA4 ・ CD14 — ITGA4 ・ F13A1 — ITGA4 ・ FN1 — ITGA4 ・ ICAM4 — ITGA4 ・ MADCAM1 — ITGA4 ・ MDK — ITGA4 ・ TGM2 — ITGA4 ・ THBS1 — ITGA4 ・ THBS2 — ITGA4 ・ VCAM1 — ITGA4 ・ ADAM11 — ITGA4 ・ ADAM23 — ITGA4 ・ ADAM29 — ITGA4 ・ ADAM7 — ITGA4 ・ CXCL12 — ITGA4 ・ PLA2G2A — ITGA4 ・ SPON2 — ITGA4 ・ ADAM2 — ITGA4 ・ CD40LG — ITGA4 ・ CX3CL1 — ITGA4 ・ JAM2 — ITGA4 ・ MIA — ITGA4 ・ PLAUR — ITGA4 ・ SVEP1 — ITGA4 ・ VWF — ITGA4