CDB15:0001346 SEMA3B — NRP1

Experimentally validated in Mouse; Orthology-inferred in Human, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

Semaphorins A and E act as antagonists of neuropilin-1 and agonists of neuropilin-2 receptors.

Nature neuroscience, 1998; PubMed, Mus Musculus Sema3b — Mus Musculus Nrp1

ABSTRACT: Neuropilin-1 (NP-1) has been identified as a necessary component of a semaphorin D (SemD) receptor that repulses dorsal root ganglion (DRG) axons during development. SemA and SemE are related to SemD and bind to NP-1, but do not repulse DRG axons. By expressing NP-1 in retinal neurons and NP-2 in DRG neurons, we demonstrate that neuropilins are sufficient to determine the functional specificity of semaphorin responsiveness. SemA and SemE block SemD binding to NP-1 and abolish SemD repulsion in axons expressing NP-1. SemA and SemE seem to have a newly discovered protein antagonist capacity at NP-1 receptors, whereas they act as agonists at receptors containing NP-2.

Basic Information on SEMA3B

Ligand Name: semaphorin 3B

Other Symbols: SEMAA, SemA, semaV, LUCA-1, sema5

Ligand Location: secreted based on perplexity, uniprot

HGNC Gene Symbol Report: SEMA3B

GeneCards: SEMA3B

HGNC Gene Group: MicroRNA host genes, Immunoglobulin superfamily domain containing, Semaphorins

Functional Annotations for SEMA3B

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for SEMA3B

SEMA3B — NRP2 ・ SEMA3B — PLXNA2 ・ SEMA3B — PLXNA4

Basic Information on NRP1

Receptor Name: neuropilin 1

Other Symbols: NRP, VEGF165R, CD304

Receptor Location: cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: NRP1

GeneCards: NRP1

HGNC Gene Group: CD molecules

Functional Annotations for NRP1

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for NRP1

CNTN2 — NRP1 ・ FGF1 — NRP1 ・ FGF2 — NRP1 ・ FGF4 — NRP1 ・ FGF7 — NRP1 ・ PGF — NRP1 ・ SEMA3A — NRP1 ・ SEMA3C — NRP1 ・ SEMA3D — NRP1 ・ SEMA3F — NRP1 ・ VEGFA — NRP1 ・ VEGFB — NRP1 ・ ALCAM — NRP1 ・ C3 — NRP1 ・ C4A — NRP1 ・ CXCL17 — NRP1 ・ EGF — NRP1 ・ FGFBP1 — NRP1 ・ FGFR1 — NRP1 ・ HGF — NRP1 ・ L1CAM — NRP1 ・ NRP1 — NRP1 ・ PRNP — NRP1 ・ PTN — NRP1 ・ SEMA4A — NRP1 ・ SERPINC1 — NRP1