CDB25:0004144 PTN — NRP1

Experimentally validated in Human; Orthology-inferred in Mouse, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

Pleiotrophin exerts its migration and invasion effect through the neuropilin-1 pathway.

Neoplasia, 2015; PubMed, Homo sapiens PTN — Homo sapiens NRP1

ABSTRACT: Pleiotrophin (PTN) is a pleiotropic growth factor that exhibits angiogenic properties and is involved in tumor growth and metastasis. Although it has been shown that PTN is expressed in tumor cells, few studies have investigated its receptors and their involvement in cell migration and invasion. Neuropilin-1 (NRP-1) is a receptor for multiple growth factors that mediates cell motility and plays an important role in angiogenesis and tumor progression. Here we provide evidence for the first time that NRP-1 is crucial for biological activities of PTN. We found that PTN interacted directly with NRP-1 through its thrombospondin type-I repeat domains. Importantly, binding of PTN to NRP-1 stimulated the internalization and recycling of NRP-1 at the cell surface. Invalidation of NRP-1 by RNA interference in human carcinoma cells inhibited PTN-induced intracellular signaling of the serine-threonine kinase, mitogen-activated protein MAP kinase, and focal adhesion kinase pathways. Accordingly, NRP-1 silencing or blocking by antibody inhibited PTN-induced human umbilical vein endothelial cell migration and tumor cell invasion. These results suggest that NRP-1/PTN interaction provides a novel mechanism for controlling the response of endothelial and tumoral cells to PTN and may explain, at least in part, how PTN contributes to tumor angiogenesis and cancer progression.

Basic Information on PTN

Ligand Name: pleiotrophin

Other Symbols: NEGF1, HBNF, HBGF8

Ligand Location: secreted based on hpa, perplexity, uniprot

HGNC Gene Symbol Report: PTN

GeneCards: PTN

HGNC Gene Group: Receptor ligands

Functional Annotations for PTN

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for PTN

PTN — ALK ・ PTN — PTPRB ・ PTN — PTPRZ1 ・ PTN — SDC1 ・ PTN — SDC3 ・ PTN — ITGAM ・ PTN — ITGAV ・ PTN — ITGB2 ・ PTN — ITGB3 ・ PTN — KDR ・ PTN — MFRP ・ PTN — RNF167 ・ PTN — ROR1 ・ PTN — SDC2 ・ PTN — SDC4

Basic Information on NRP1

Receptor Name: neuropilin 1

Other Symbols: NRP, VEGF165R, CD304

Receptor Location: cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: NRP1

GeneCards: NRP1

HGNC Gene Group: CD molecules

Functional Annotations for NRP1

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for NRP1

CNTN2 — NRP1 ・ FGF1 — NRP1 ・ FGF2 — NRP1 ・ FGF4 — NRP1 ・ FGF7 — NRP1 ・ PGF — NRP1 ・ SEMA3A — NRP1 ・ SEMA3B — NRP1 ・ SEMA3C — NRP1 ・ SEMA3D — NRP1 ・ SEMA3F — NRP1 ・ VEGFA — NRP1 ・ VEGFB — NRP1 ・ ALCAM — NRP1 ・ C3 — NRP1 ・ C4A — NRP1 ・ CXCL17 — NRP1 ・ EGF — NRP1 ・ FGFBP1 — NRP1 ・ FGFR1 — NRP1 ・ HGF — NRP1 ・ L1CAM — NRP1 ・ NRP1 — NRP1 ・ PRNP — NRP1 ・ SEMA4A — NRP1 ・ SERPINC1 — NRP1