CDB25:0004147 PTN — SDC2

Experimentally validated in Human; Orthology-inferred in Mouse, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

PTN from Leydig cells activates SDC2 and modulates human spermatogonial stem cell proliferation and survival via GFRA1.

Biological research, 2024; PubMed, Homo sapiens PTN — Homo sapiens SDC2

ABSTRACT: Spermatogonial stem cells (SSCs) are essential for the maintenance and initiation of male spermatogenesis. Despite the advances in understanding SSC biology in mouse models, the mechanisms underlying human SSC development remain elusive.

Basic Information on PTN

Ligand Name: pleiotrophin

Other Symbols: NEGF1, HBNF, HBGF8

Ligand Location: secreted based on hpa, perplexity, uniprot

HGNC Gene Symbol Report: PTN

GeneCards: PTN

HGNC Gene Group: Receptor ligands

Functional Annotations for PTN

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for PTN

PTN — ALK ・ PTN — PTPRB ・ PTN — PTPRZ1 ・ PTN — SDC1 ・ PTN — SDC3 ・ PTN — ITGAM ・ PTN — ITGAV ・ PTN — ITGB2 ・ PTN — ITGB3 ・ PTN — KDR ・ PTN — MFRP ・ PTN — NRP1 ・ PTN — RNF167 ・ PTN — ROR1 ・ PTN — SDC4

Basic Information on SDC2

Receptor Name: syndecan 2

Other Symbols: HSPG, HSPG1, fibroglycan, SYND2, CD362

Receptor Location: cell membrane based on hpa, perplexity

HGNC Gene Symbol Report: SDC2

GeneCards: SDC2

HGNC Gene Group: CD molecules, Proteoglycans

Functional Annotations for SDC2

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for SDC2

CSF2 — SDC2 ・ FGF2 — SDC2 ・ FN1 — SDC2 ・ CXCL8 — SDC2 ・ LAMA3 — SDC2 ・ PF4 — SDC2 ・ TGFB1 — SDC2 ・ ANGPTL4 — SDC2 ・ FGF1 — SDC2 ・ HRG — SDC2