CDB25:0003517 EGF — NRP1

Experimentally validated in Human; Orthology-inferred in Mouse, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset

Title

Journal:; Year Published:

Abstract

Secretoneurin induces airway mucus hypersecretion by enhancing the binding of EGF to NRP1.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2014; PubMed, Homo sapiens EGF — Homo sapiens NRP1

ABSTRACT: Secretoneurin(SN), a neuropeptide, has been considered a reliable marker of allergenic stimulation. However, the relationship between SN and the secretion of airway mucin remains unclear. In this study, we aimed to examine the in vitro relationship between SN and airway mucin over synthesis, as well as the signaling pathways involved.

Basic Information on EGF

Ligand Name: epidermal growth factor

Other Symbols: N/A

Ligand Location: secreted based on perplexity

HGNC Gene Symbol Report: EGF

GeneCards: EGF

HGNC Gene Group: unknown

Functional Annotations for EGF

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for EGF

EGF — EGFR ・ EGF — ERBB2 ・ EGF — ERBB3 ・ EGF — ERBB4 ・ EGF — AXL

Basic Information on NRP1

Receptor Name: neuropilin 1

Other Symbols: NRP, VEGF165R, CD304

Receptor Location: cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: NRP1

GeneCards: NRP1

HGNC Gene Group: CD molecules

Functional Annotations for NRP1

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for NRP1

CNTN2 — NRP1 ・ FGF1 — NRP1 ・ FGF2 — NRP1 ・ FGF4 — NRP1 ・ FGF7 — NRP1 ・ PGF — NRP1 ・ SEMA3A — NRP1 ・ SEMA3B — NRP1 ・ SEMA3C — NRP1 ・ SEMA3D — NRP1 ・ SEMA3F — NRP1 ・ VEGFA — NRP1 ・ VEGFB — NRP1 ・ ALCAM — NRP1 ・ C3 — NRP1 ・ C4A — NRP1 ・ CXCL17 — NRP1 ・ FGFBP1 — NRP1 ・ FGFR1 — NRP1 ・ HGF — NRP1 ・ L1CAM — NRP1 ・ NRP1 — NRP1 ・ PRNP — NRP1 ・ PTN — NRP1 ・ SEMA4A — NRP1 ・ SERPINC1 — NRP1