CDB15:0001347 SEMA3B — NRP2

Experimentally validated in Mixed species; Orthology-inferred in Human, Mouse, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

Semaphorins A and E act as antagonists of neuropilin-1 and agonists of neuropilin-2 receptors.

Nature neuroscience, 1998; PubMed, Mus Musculus Sema3b — Rattus norvegicus Nrp2

ABSTRACT: Neuropilin-1 (NP-1) has been identified as a necessary component of a semaphorin D (SemD) receptor that repulses dorsal root ganglion (DRG) axons during development. SemA and SemE are related to SemD and bind to NP-1, but do not repulse DRG axons. By expressing NP-1 in retinal neurons and NP-2 in DRG neurons, we demonstrate that neuropilins are sufficient to determine the functional specificity of semaphorin responsiveness. SemA and SemE block SemD binding to NP-1 and abolish SemD repulsion in axons expressing NP-1. SemA and SemE seem to have a newly discovered protein antagonist capacity at NP-1 receptors, whereas they act as agonists at receptors containing NP-2.

Basic Information on SEMA3B

Ligand Name: semaphorin 3B

Other Symbols: SEMAA, SemA, semaV, LUCA-1, sema5

Ligand Location: secreted based on perplexity, uniprot

HGNC Gene Symbol Report: SEMA3B

GeneCards: SEMA3B

HGNC Gene Group: MicroRNA host genes, Immunoglobulin superfamily domain containing, Semaphorins

Functional Annotations for SEMA3B

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for SEMA3B

SEMA3B — NRP1 ・ SEMA3B — PLXNA2 ・ SEMA3B — PLXNA4

Basic Information on NRP2

Receptor Name: neuropilin 2

Other Symbols: VEGF165R2

Receptor Location: cell membrane based on hpa, perplexity

HGNC Gene Symbol Report: NRP2

GeneCards: NRP2

HGNC Gene Group: unknown

Functional Annotations for NRP2

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for NRP2

VEGFD — NRP2 ・ PGF — NRP2 ・ SEMA3A — NRP2 ・ SEMA3C — NRP2 ・ SEMA3F — NRP2 ・ SEMA3G — NRP2 ・ VEGFA — NRP2 ・ VEGFC — NRP2 ・ ANGPTL4 — NRP2 ・ HGF — NRP2 ・ SEMA3D — NRP2