CDB20:0002833 MICA — KLRK1

Experimentally validated in Human; Orthology-inferred in Rat, Zebrafish, Macaque, Dog, Cow, Chimp, Marmoset

Title

Journal:; Year Published:

Abstract

Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA.

Science, 1999; PubMed, Homo sapiens MICA — Homo sapiens KLRK1

ABSTRACT: Stress-inducible MICA, a distant homolog of major histocompatibility complex (MHC) class I, functions as an antigen for gammadelta T cells and is frequently expressed in epithelial tumors. A receptor for MICA was detected on most gammadelta T cells, CD8+ alphabeta T cells, and natural killer (NK) cells and was identified as NKG2D. Effector cells from all these subsets could be stimulated by ligation of NKG2D. Engagement of NKG2D activated cytolytic responses of gammadelta T cells and NK cells against transfectants and epithelial tumor cells expressing MICA. These results define an activating immunoreceptor-MHC ligand interaction that may promote antitumor NK and T cell responses.

Basic Information on MICA

Ligand Name: MHC class I polypeptide-related sequence A

Other Symbols: PERB11.1

Ligand Location: cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: MICA

GeneCards: MICA

HGNC Gene Group: Immunoglobulin superfamily domain containing

Functional Annotations for MICA

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for MICA

Basic Information on KLRK1

Receptor Name: killer cell lectin like receptor K1

Other Symbols: D12S2489E, NKG2D, KLR, NKG2-D, CD314

Receptor Location: cell membrane based on hpa, perplexity, uniprot

HGNC Gene Symbol Report: KLRK1

GeneCards: KLRK1

HGNC Gene Group: C-type lectin domain containing, CD molecules, Killer cell lectin like receptors

Functional Annotations for KLRK1

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for KLRK1

RAET1E — KLRK1 ・ ULBP2 — KLRK1 ・ MICB — KLRK1 ・ RAET1G — KLRK1 ・ RAET1L — KLRK1 ・ ULBP1 — KLRK1 ・ ULBP3 — KLRK1 ・ RAE1 — KLRK1