CDB20:0002832 MDK — NOTCH2

Experimentally validated in Human; Orthology-inferred in Mouse, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

Midkine induces epithelial-mesenchymal transition through Notch2/Jak2-Stat3 signaling in human keratinocytes.

Cell cycle, 2008; PubMed, Homo sapiens MDK — Homo sapiens NOTCH2

ABSTRACT: Epithelial-to-mesenchymal transition (EMT) underlies cell plasticity and embryonic development and is frequently observed in advanced tumorigenesis. We demonstrated that midkine (MK), a retinoic acid-inducible heparin-binding mitogen, promotes EMT in immortalized HaCaT keratinocytes. We showed that MK binds to the Notch2 receptor in HaCaT keratinocytes. We further found that MK activates Notch2 signaling leading to protein/protein interactions between Hes1 and Jak2/Stat3 intermediates. We thus suggest that MK-induced cross talk of Notch2/Jak2/Stat3 signaling pathways can regulate cell plasticity and motility contributing to the EMT and later stages of tumorigenesis.

Basic Information on MDK

Ligand Name: midkine

Other Symbols: NEGF2, MK, FLJ27379

Ligand Location: secreted based on hpa, perplexity, uniprot

HGNC Gene Symbol Report: MDK

GeneCards: MDK

HGNC Gene Group: unknown

Functional Annotations for MDK

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for MDK

MDK — ALK ・ MDK — ITGA4 ・ MDK — ITGA6 ・ MDK — ITGB1 ・ MDK — LRP1 ・ MDK — PTPRZ1 ・ MDK — SDC1 ・ MDK — SDC3 ・ MDK — SDC4 ・ MDK — TSPAN1 ・ MDK — RNF167

Basic Information on NOTCH2

Receptor Name: notch receptor 2

Other Symbols: N/A

Receptor Location: cell membrane based on hpa, perplexity, uniprot

HGNC Gene Symbol Report: NOTCH2

GeneCards: NOTCH2

HGNC Gene Group: Ankyrin repeat domain containing

Functional Annotations for NOTCH2

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for NOTCH2

DLL1 — NOTCH2 ・ DLL4 — NOTCH2 ・ JAG1 — NOTCH2 ・ JAG2 — NOTCH2 ・ MFNG — NOTCH2 ・ CNTN1 — NOTCH2 ・ APP — NOTCH2 ・ EGFL7 — NOTCH2 ・ MFAP5 — NOTCH2