CDB15:0001064 MDK — TSPAN1

Experimentally validated in Human; Orthology-inferred in Mouse, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

Midkine promotes tetraspanin-integrin interaction and induces FAK-Stat1alpha pathway contributing to migration/invasiveness of human head and neck squamous cell carcinoma cells.

Biochemical and biophysical research communications, 2008; PubMed, Homo sapiens MDK — Homo sapiens TSPAN1

ABSTRACT: The heparin-binding growth factor, MK, promoting tumorigenesis and survival was found to associate with alpha6beta1 integrins. We showed for the first time that MK interacted with TSPAN1 and facilitated the association between TSPAN1 and integrin alpha6beta1 proteins in head and neck squamous cell carcinoma (HNSCC) cells. We found that MK mediated an integrin-dependent tyrosine phosphorylation of FAK and activation of paxillin and Stat1alpha pathways. As result, downstream target genes implicated in cell migration and invasiveness (e.g. MMP-2 and MMP-26) were overexpressed. We observed that RNAi silencing of the critical signaling intermediates led to decrease of MK-induced migration/invasiveness of HNSCC cells. The major finding of this study is a novel MK-triggered signaling mechanism implicated in migration and invasiveness of HNSCC cells.

Basic Information on MDK

Ligand Name: midkine

Other Symbols: NEGF2, MK, FLJ27379

Ligand Location: secreted based on hpa, perplexity, uniprot

HGNC Gene Symbol Report: MDK

GeneCards: MDK

HGNC Gene Group: unknown

Functional Annotations for MDK

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for MDK

MDK — ALK ・ MDK — ITGA4 ・ MDK — ITGA6 ・ MDK — ITGB1 ・ MDK — LRP1 ・ MDK — PTPRZ1 ・ MDK — SDC1 ・ MDK — SDC3 ・ MDK — SDC4 ・ MDK — NOTCH2 ・ MDK — RNF167

Basic Information on TSPAN1

Receptor Name: tetraspanin 1

Other Symbols: TSPAN-1, NET-1

Receptor Location: cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: TSPAN1

GeneCards: TSPAN1

HGNC Gene Group: Tetraspanins

Functional Annotations for TSPAN1

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for TSPAN1