CDB25:0004172 RAE1 — KLRK1

Experimentally validated in Mixed species; Orthology-inferred in Human, Mouse, Rat, Zebrafish, Macaque, Pig, Dog, Cow, Chimp, Horse, Sheep

Title

Journal:; Year Published:

Abstract

Retinoic acid early inducible genes define a ligand family for the activating NKG2D receptor in mice.

Immunity, 2000; PubMed, Homo sapiens RAE1 — Mus Musculus Klrk1

ABSTRACT: Here we describe a family of GPI-anchored cell surface proteins that function as ligands for the mouse activating NKG2D receptor. These molecules are encoded by the retinoic acid early inducible (RAE-1) and H60 minor histocompatibility antigen genes on mouse chromosome 10 and show weak homology with MHC class I. Expression of the NKG2D ligands is low or absent on normal, adult tissues; however, they are constitutively expressed on some tumors and upregulated by retinoic acid. Ectopic expression of RAE-1 and H60 confers target susceptibility to NK cell attack. These studies identify a family of ligands for the activating NKG2D receptor on NK and T cells, which may play an important role in innate and adaptive immunity.

Basic Information on RAE1

Ligand Name: ribonucleic acid export 1

Other Symbols: Mnrp41, Gle2

Ligand Location: GPI-anchored cell membrane based on PMID: 10894171

HGNC Gene Symbol Report: RAE1

GeneCards: RAE1

HGNC Gene Group: Nucleoporins, WD repeat domain containing

Functional Annotations for RAE1

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for RAE1

Basic Information on KLRK1

Receptor Name: killer cell lectin like receptor K1

Other Symbols: D12S2489E, NKG2D, KLR, NKG2-D, CD314

Receptor Location: cell membrane based on hpa, perplexity, uniprot

HGNC Gene Symbol Report: KLRK1

GeneCards: KLRK1

HGNC Gene Group: C-type lectin domain containing, CD molecules, Killer cell lectin like receptors

Functional Annotations for KLRK1

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for KLRK1

RAET1E — KLRK1 ・ ULBP2 — KLRK1 ・ MICA — KLRK1 ・ MICB — KLRK1 ・ RAET1G — KLRK1 ・ RAET1L — KLRK1 ・ ULBP1 — KLRK1 ・ ULBP3 — KLRK1