CDB15:0001524 ULBP2 — KLRK1

Experimentally validated in Human; Orthology-inferred in Zebrafish, Macaque, Pig, Chimp, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor.

Immunity, 2001; PubMed, Homo sapiens ULBP2 — Homo sapiens KLRK1

ABSTRACT: The human cytomegalovirus glycoprotein, UL16, binds to two members of a novel family of molecules, the ULBPs, and to the MHC class I homolog, MICB. The ULBPs are GPI-linked glycoproteins belonging to the extended MHC class I family but are only distantly related to MICB. The ULBP and MICB molecules are ligands for the activating receptor, NKG2D/DAP10, and this interaction is blocked by a soluble form of UL16. The ULBPs stimulate cytokine and chemokine production from NK cells, and expression of ULBPs in NK cell-resistant target cells confers susceptibility to NK cell cytotoxicity. Masking of NK cell recognition of ULBP or MIC antigens by UL16 provides a potential mechanism by which human cytomegalovirus-infected cells might evade attack by the immune system.

Basic Information on ULBP2

Ligand Name: UL16 binding protein 2

Other Symbols: RAET1H

Ligand Location: secreted based on hpa, perplexity, uniprot, cell membrane based on hpa, perplexity, uniprot

HGNC Gene Symbol Report: ULBP2

GeneCards: ULBP2

HGNC Gene Group: unknown

Functional Annotations for ULBP2

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for ULBP2

Basic Information on KLRK1

Receptor Name: killer cell lectin like receptor K1

Other Symbols: D12S2489E, NKG2D, KLR, NKG2-D, CD314

Receptor Location: cell membrane based on hpa, perplexity, uniprot

HGNC Gene Symbol Report: KLRK1

GeneCards: KLRK1

HGNC Gene Group: C-type lectin domain containing, CD molecules, Killer cell lectin like receptors

Functional Annotations for KLRK1

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for KLRK1

RAET1E — KLRK1 ・ MICA — KLRK1 ・ MICB — KLRK1 ・ RAET1G — KLRK1 ・ RAET1L — KLRK1 ・ ULBP1 — KLRK1 ・ ULBP3 — KLRK1 ・ RAE1 — KLRK1