CDB15:0001019 LCN2 — LRP2

Experimentally validated in Human; Orthology-inferred in Mouse, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

The endocytic receptor megalin binds the iron transporting neutrophil-gelatinase-associated lipocalin with high affinity and mediates its cellular uptake.

FEBS letters, 2005; PubMed, Homo sapiens LCN2 — Homo sapiens LRP2

ABSTRACT: Neutrophil-gelatinase-associated lipocalin (NGAL) is a prominent protein of specific granules of human neutrophils also synthesized by epithelial cells during inflammation. NGAL binds bacterial siderophores preventing bacteria from retrieving iron from this source. Also, NGAL may be important in delivering iron to cells during formation of the tubular epithelial cells of the primordial kidney. No cellular receptor for NGAL has been described. We show here that megalin, a member of the low-density lipoprotein receptor family expressed in polarized epithelia, binds NGAL with high affinity, as shown by surface plasmon resonance analysis. Furthermore, a rat yolk sac cell line known to express high levels of megalin, endocytosed NGAL by a mechanism completely blocked by an antibody against megalin.

Basic Information on LCN2

Ligand Name: lipocalin 2

Other Symbols: NGAL, 24p3

Ligand Location: secreted based on hpa, perplexity, uniprot

HGNC Gene Symbol Report: LCN2

GeneCards: LCN2

HGNC Gene Group: Calycin structural superfamily

Functional Annotations for LCN2

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for LCN2

LCN2 — MC4R ・ LCN2 — SLC22A17

Basic Information on LRP2

Receptor Name: LDL receptor related protein 2

Other Symbols: gp330, DBS

Receptor Location: cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: LRP2

GeneCards: LRP2

HGNC Gene Group: Low density lipoprotein receptors

Functional Annotations for LRP2

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for LRP2

AGT — LRP2 ・ ALB — LRP2 ・ APOB — LRP2 ・ APOE — LRP2 ・ INS — LRP2 ・ LEP — LRP2 ・ LPA — LRP2 ・ LPL — LRP2 ・ LRPAP1 — LRP2 ・ PLAU — LRP2 ・ SCGB1A1 — LRP2 ・ SERPINE1 — LRP2 ・ SHH — LRP2 ・ TCN2 — LRP2 ・ TG — LRP2 ・ APOM — LRP2 ・ APP — LRP2 ・ CLU — LRP2 ・ CRIPTO — LRP2 ・ CST3 — LRP2 ・ GC — LRP2 ・ LTF — LRP2