CDB15:0001020 LEFTY2 — ACVR2B

Experimentally validated in Mixed species, Mouse; Orthology-inferred in Human, Mouse, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Sheep

Title

Journal:; Year Published:

Abstract

Inhibition of Nodal signalling by Lefty mediated through interaction with common receptors and efficient diffusion.

Genes to cells : devoted to molecular & cellular mechanisms, 2002; PubMed, Mus Musculus Lefty2 — Mus Musculus Acvr2b
ABSTRACT: Two TGFbeta-related proteins, Nodal and Lefty, are implicated in early embryonic patterning of vertebrates. Genetic data suggest that Nodal is a signalling molecule, while Lefty is an antagonist of Nodal, but their precise function remains unknown.
Basic Information on LEFTY2
Ligand Name: left-right determination factor 2
Other Symbols: TGFB4, EBAF, LEFTA, LEFTYA
Ligand Location: secreted based on perplexity, uniprot
HGNC Gene Symbol Report: LEFTY2
GeneCards: LEFTY2
Functional Annotations for LEFTY2
Gene Ontologies: PAN-GO, AmiGO 2
Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)
Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)
Interactions with other Receptors for LEFTY2
LEFTY2 — ACVR2A
Basic Information on ACVR2B
Receptor Name: activin A receptor type 2B
Other Symbols: ActR-IIB
Receptor Location: cell membrane based on perplexity, uniprot
HGNC Gene Symbol Report: ACVR2B
GeneCards: ACVR2B
HGNC Gene Group: Receptor kinases
Functional Annotations for ACVR2B
Gene Ontologies: PAN-GO, AmiGO 2
Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)
Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)
Interactions with other Ligands for ACVR2B
BMP10 — ACVR2B ・ BMP2 — ACVR2B ・ BMP3 — ACVR2B ・ BMP6 — ACVR2B ・ BMP7 — ACVR2B ・ GDF11 — ACVR2B ・ GDF2 — ACVR2B ・ GDF5 — ACVR2B ・ INHA — ACVR2B ・ INHBA — ACVR2B ・ INHBB — ACVR2B ・ INHBC — ACVR2B ・ MSTN — ACVR2B ・ NODAL — ACVR2B ・ CRIPTO — ACVR2B ・ BMP8A — ACVR2B ・ GDF1 — ACVR2B ・ GDF3 — ACVR2B ・ GDF6 — ACVR2B ・ GDF7 — ACVR2B ・ INHBE — ACVR2B ・ LEFTY1 — ACVR2B
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