CDB25:0003681 GDF6 — ACVR2B

Experimentally validated in Human; Orthology-inferred in Mouse, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

Divergent activities of osteogenic BMP2, and tenogenic BMP12 and BMP13 independent of receptor binding affinities.

Growth factors, 2011; PubMed, Homo sapiens GDF6 — Homo sapiens ACVR2B
ABSTRACT: Ectopic expression of recombinant human bone morphogenetic protein 2 (rhBMP2) induces osteogenesis, while ectopic expression of rhBMP12 and rhBMP13 induces the formation of tendon-like tissue. Despite their different in vivo activities, all three ligands bound to the type I bone morphogenic protein receptors (BMPRs), activin receptor-like kinase (ALK)-3 and ALK6, and to the type II BMPRs, activin receptor type-2A, activin receptor type-2B, and BMPR2, with similar affinities. Treatment of C3H10T1/2 cells with rhBMP2 activated SMAD signaling and induced expression of osteoblast markers including osteocalcin mRNA (Ocn). In contrast, treatment with rhBMP12 or rhBMP13 resulted in a dose-dependent induction of a tendon-specific gene (Thbs4) expression with no detectable activation of SMAD 1, 5, and 8. Differential regulation of Thbs4 and Ocn has potential utility as an in vitro biomarker for induction of tenogenic signaling. Such an assay also permits the ability to distinguish between the activities of different BMPs and may prove useful in studies on the molecular mechanisms of BMP tenogenic activity.
Basic Information on GDF6
Ligand Name: growth differentiation factor 6
Other Symbols: SGM1, BMP13, KFS, KFS1
Ligand Location: secreted based on hpa, perplexity, uniprot
HGNC Gene Symbol Report: GDF6
GeneCards: GDF6
Functional Annotations for GDF6
Gene Ontologies: PAN-GO, AmiGO 2
Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)
Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)
Interactions with other Receptors for GDF6
GDF6 — BMPR1A ・ GDF6 — BMPR1B ・ GDF6 — BMPR2 ・ GDF6 — ACVR2A
Basic Information on ACVR2B
Receptor Name: activin A receptor type 2B
Other Symbols: ActR-IIB
Receptor Location: cell membrane based on perplexity, uniprot
HGNC Gene Symbol Report: ACVR2B
GeneCards: ACVR2B
HGNC Gene Group: Receptor kinases
Functional Annotations for ACVR2B
Gene Ontologies: PAN-GO, AmiGO 2
Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)
Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)
Interactions with other Ligands for ACVR2B
BMP10 — ACVR2B ・ BMP2 — ACVR2B ・ BMP3 — ACVR2B ・ BMP6 — ACVR2B ・ BMP7 — ACVR2B ・ GDF11 — ACVR2B ・ GDF2 — ACVR2B ・ GDF5 — ACVR2B ・ INHA — ACVR2B ・ INHBA — ACVR2B ・ INHBB — ACVR2B ・ INHBC — ACVR2B ・ LEFTY2 — ACVR2B ・ MSTN — ACVR2B ・ NODAL — ACVR2B ・ CRIPTO — ACVR2B ・ BMP8A — ACVR2B ・ GDF1 — ACVR2B ・ GDF3 — ACVR2B ・ GDF7 — ACVR2B ・ INHBE — ACVR2B ・ LEFTY1 — ACVR2B
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