CDB25:0003664 GC — LRP2

Experimentally validated in Rat; Orthology-inferred in Human, Mouse, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

Gc-globulin (vitamin D binding protein) is synthesized and secreted by hepatocytes and internalized by hepatic stellate cells through Ca(2+)-dependent interaction with the megalin/gp330 receptor.

Clinica chimica acta; international journal of clinical chemistry, 2008; PubMed, Rattus norvegicus Gc — Rattus norvegicus Lrp2

ABSTRACT: Gc-globulin or vitamin D binding protein is a highly expressed, multifunctional and polymorphic serum protein, which also serves as the major transporter for vitamin D metabolites in the circulation. The present study was performed to analyze the interaction between gc-globulin of hepatocytes and hepatic stellate cells, the most important fat-/retinol-storing cell type in the liver, which spontaneously transdifferentiates to myofibroblasts in culture.

Basic Information on GC

Ligand Name: GC vitamin D binding protein

Other Symbols: DBP, VDBP, hDBP

Ligand Location: secreted based on perplexity, uniprot

HGNC Gene Symbol Report: GC

GeneCards: GC

HGNC Gene Group: Albuminoid family

Functional Annotations for GC

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for GC

Basic Information on LRP2

Receptor Name: LDL receptor related protein 2

Other Symbols: gp330, DBS

Receptor Location: cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: LRP2

GeneCards: LRP2

HGNC Gene Group: Low density lipoprotein receptors

Functional Annotations for LRP2

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for LRP2

AGT — LRP2 ・ ALB — LRP2 ・ APOB — LRP2 ・ APOE — LRP2 ・ INS — LRP2 ・ LCN2 — LRP2 ・ LEP — LRP2 ・ LPA — LRP2 ・ LPL — LRP2 ・ LRPAP1 — LRP2 ・ PLAU — LRP2 ・ SCGB1A1 — LRP2 ・ SERPINE1 — LRP2 ・ SHH — LRP2 ・ TCN2 — LRP2 ・ TG — LRP2 ・ APOM — LRP2 ・ APP — LRP2 ・ CLU — LRP2 ・ CRIPTO — LRP2 ・ CST3 — LRP2 ・ LTF — LRP2