CDB25:0003609 FCER2 — ITGAM

Experimentally validated in Human; Orthology-inferred in Mouse, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

CD23 regulates monocyte activation through a novel interaction with the adhesion molecules CD11b-CD18 and CD11c-CD18.

Immunity, 1995; PubMed, Homo sapiens FCER2 — Homo sapiens ITGAM

ABSTRACT: CD23 is expressed on a variety of haemopoietic cells and displays pleiotropic activities in vitro. We report that in addition to CD21 and IgE, CD23 interacts specifically with the CD11b and CD11c, the alpha chains of the beta 2 integrin adhesion molecule complexes CD11b-CD18 and CD11c-CD18, on monocytes. Full-length recombinant CD23 incorporated into fluorescent liposomes was shown to bind to COS cells transfected with cDNA encoding either CD11b-CD18 or CD11c-CD18 but not with CD11a-CD18. The interaction was specifically inhibited by anti-CD11b or anti-CD11c, respectively, and by anti-CD23 MAbs. The functional significance of this ligand pairing was demonstrated by triggering CD11b and CD11c on monocytes with either recombinant CD23 or anti-CD11b and anti-CD11c MAbs to cause a marked increase in nitrite-oxidative products and pro-inflammatory cytokines (IL-1 beta, IL-6, and TNF alpha). These CD23-mediated activities were decreased by Fab fragments of MAbs to CD11b, CD11c, and CD23. These results demonstrate that CD11b and CD11c are receptors for CD23 and that this novel ligand pairing regulates important activities of monocytes.

Basic Information on FCER2

Ligand Name: Fc epsilon receptor II

Other Symbols: CD23A, FCE2, CLEC4J, CD23, FCErII, FcepsilonRII

Ligand Location: secreted based on perplexity, uniprot, cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: FCER2

GeneCards: FCER2

HGNC Gene Group: C-type lectin domain containing, Fc receptors, CD molecules

Functional Annotations for FCER2

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for FCER2

FCER2 — CR2 ・ FCER2 — ITGAV ・ FCER2 — ITGAX ・ FCER2 — ITGB2 ・ FCER2 — ITGB3 ・ FCER2 — ITGB5

Basic Information on ITGAM

Receptor Name: integrin subunit alpha M

Other Symbols: CR3A, CD11B, MAC-1, CD11b

Receptor Location: cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: ITGAM

GeneCards: ITGAM

HGNC Gene Group: CD molecules, Complement system, Integrins

Functional Annotations for ITGAM

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for ITGAM

C3 — ITGAM ・ CD40LG — ITGAM ・ CFH — ITGAM ・ CCN2 — ITGAM ・ CCN1 — ITGAM ・ F10 — ITGAM ・ FGA — ITGAM ・ HP — ITGAM ・ ICAM1 — ITGAM ・ ICAM2 — ITGAM ・ ICAM4 — ITGAM ・ KNG1 — ITGAM ・ LPA — ITGAM ・ PLAT — ITGAM ・ PLAU — ITGAM ・ SPON2 — ITGAM ・ FGG — ITGAM ・ GP1BA — ITGAM ・ JAM3 — ITGAM ・ PTN — ITGAM ・ SIGLEC15 — ITGAM ・ THY1 — ITGAM