CDB15:0000158 C3 — ITGAM

Experimentally validated in Human; Orthology-inferred in Mouse, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

Isolation of complement-fragment-iC3b-binding proteins by affinity chromatography. The identification of p150,95 as an iC3b-binding protein.

The Biochemical journal, 1985; PubMed, Homo sapiens C3 — Homo sapiens ITGAM

ABSTRACT: The proteins from labelled human spleen membranes and polymorphonuclear leucocytes which bind to the iC3b fragment of complement component C3 were prepared by iC3b-Sepharose chromatography in the presence of bivalent cations. Complement receptor type 3(CR3) was eluted from iC3b-Sepharose by removal of bivalent cations. Complement receptors type 1 and 2 (present in spleen but not in polymorphonuclear leucocytes) were sequentially eluted by an NaCl gradient. An additional protein of Mr 135 000 was eluted from iC3b-Sepharose under the same conditions as those used to elute CR3. Preabsorption of the starting material on an anti-(CR3 beta-subunit) antibody column before iC3b-Sepharose chromatography removed the alpha- and beta-chains of CR3 and the 135 000-Mr protein. Preabsorption with iC3b-Sepharose before the anti-(CR3 beta-subunit) antibody column showed that iC3b binds CR3 and p150,95, the smallest member of the group of three homologous proteins that share the same beta-subunit.

Basic Information on C3

Ligand Name: complement C3

Other Symbols: CPAMD1, ARMD9, C3a, C3b

Ligand Location: secreted based on perplexity, uniprot

HGNC Gene Symbol Report: C3

GeneCards: C3

HGNC Gene Group: C3 and PZP like, alpha-2-macroglobulin domain containing, Complement system, Receptor ligands

Functional Annotations for C3

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for C3

C3 — C3AR1 ・ C3 — C5AR2 ・ C3 — CR1 ・ C3 — ITGAX ・ C3 — ITGB2 ・ C3 — LRP1 ・ C3 — CR2 ・ C3 — NRP1

Basic Information on ITGAM

Receptor Name: integrin subunit alpha M

Other Symbols: CR3A, CD11B, MAC-1, CD11b

Receptor Location: cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: ITGAM

GeneCards: ITGAM

HGNC Gene Group: CD molecules, Complement system, Integrins

Functional Annotations for ITGAM

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for ITGAM

CD40LG — ITGAM ・ CFH — ITGAM ・ CCN2 — ITGAM ・ CCN1 — ITGAM ・ F10 — ITGAM ・ FGA — ITGAM ・ HP — ITGAM ・ ICAM1 — ITGAM ・ ICAM2 — ITGAM ・ ICAM4 — ITGAM ・ KNG1 — ITGAM ・ LPA — ITGAM ・ PLAT — ITGAM ・ PLAU — ITGAM ・ SPON2 — ITGAM ・ FCER2 — ITGAM ・ FGG — ITGAM ・ GP1BA — ITGAM ・ JAM3 — ITGAM ・ PTN — ITGAM ・ SIGLEC15 — ITGAM ・ THY1 — ITGAM