CDB15:0001222 PLAU — ITGAM

Experimentally validated in Human, Mouse; Orthology-inferred in Human, Rat, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep, Mouse

Title

Journal:; Year Published:

Abstract

Urokinase-type plasminogen activator promotes paracellular transmigration of neutrophils via Mac-1, but independently of urokinase-type plasminogen activator receptor.

Circulation, 2011; PubMed, Homo sapiens PLAU — Homo sapiens ITGAM

ABSTRACT: Urokinase-type plasminogen activator (uPA) has recently been implicated in the pathogenesis of ischemia-reperfusion (I/R) injury. The underlying mechanisms remain largely unclear.

Basic Information on PLAU

Ligand Name: plasminogen activator, urokinase

Other Symbols: URK, UPA

Ligand Location: secreted based on hpa, perplexity, uniprot

HGNC Gene Symbol Report: PLAU

GeneCards: PLAU

HGNC Gene Group: unknown

Functional Annotations for PLAU

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for PLAU

PLAU — LRP1 ・ PLAU — LRP2 ・ PLAU — PLAUR ・ PLAU — VLDLR

Basic Information on ITGAM

Receptor Name: integrin subunit alpha M

Other Symbols: CR3A, CD11B, MAC-1, CD11b

Receptor Location: cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: ITGAM

GeneCards: ITGAM

HGNC Gene Group: CD molecules, Complement system, Integrins

Functional Annotations for ITGAM

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for ITGAM

C3 — ITGAM ・ CD40LG — ITGAM ・ CFH — ITGAM ・ CCN2 — ITGAM ・ CCN1 — ITGAM ・ F10 — ITGAM ・ FGA — ITGAM ・ HP — ITGAM ・ ICAM1 — ITGAM ・ ICAM2 — ITGAM ・ ICAM4 — ITGAM ・ KNG1 — ITGAM ・ LPA — ITGAM ・ PLAT — ITGAM ・ SPON2 — ITGAM ・ FCER2 — ITGAM ・ FGG — ITGAM ・ GP1BA — ITGAM ・ JAM3 — ITGAM ・ PTN — ITGAM ・ SIGLEC15 — ITGAM ・ THY1 — ITGAM