CDB25:0003412 COL5A1 — DDR2

Experimentally validated in Human; Orthology-inferred in Mouse, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

An orphan receptor tyrosine kinase family whose members serve as nonintegrin collagen receptors.

Molecular cell, 1997; PubMed, Homo sapiens COL5A1 — Homo sapiens DDR2

ABSTRACT: Mammalian cells constantly monitor and respond to a myriad of extracellular signals, often by using cell surface receptors. Two important classes of cell surface receptors include the receptor tyrosine kinases, which recognize peptide growth factors such as insulin, and the integrins, which most often mediate binding to components of the extracellular matrix. We report that the collagens serve as ligands for the previously orphan family of discoidin domain-containing receptor-like tyrosine kinases. The unexpected realization that an extracellular matrix molecule can directly serve as a ligand for receptor tyrosine kinases provides an example of ligands shared by integrins and receptor tyrosine kinases, and this finding seems likely to change prevailing views about the mechanisms by which cells perceive and respond to the extracellular matrix.

Basic Information on COL5A1

Ligand Name: collagen type V alpha 1 chain

Other Symbols: N/A

Ligand Location: secreted based on hpa, perplexity, uniprot

HGNC Gene Symbol Report: COL5A1

GeneCards: COL5A1

HGNC Gene Group: Collagens

Functional Annotations for COL5A1

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for COL5A1

COL5A1 — ITGB1 ・ COL5A1 — SDC3 ・ COL5A1 — DDR1 ・ COL5A1 — ITGA2

Basic Information on DDR2

Receptor Name: discoidin domain receptor tyrosine kinase 2

Other Symbols: TYRO10, NTRKR3, TKT

Receptor Location: cell membrane based on hpa, perplexity, uniprot

HGNC Gene Symbol Report: DDR2

GeneCards: DDR2

HGNC Gene Group: Receptor kinases

Functional Annotations for DDR2

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for DDR2

COL1A1 — DDR2 ・ COL3A1 — DDR2 ・ COL11A1 — DDR2 ・ COL11A2 — DDR2 ・ COL1A2 — DDR2 ・ COL2A1 — DDR2 ・ COL4A1 — DDR2 ・ COL4A2 — DDR2 ・ COL4A3 — DDR2 ・ COL4A4 — DDR2 ・ COL4A5 — DDR2 ・ COL4A6 — DDR2 ・ COL5A2 — DDR2 ・ COL5A3 — DDR2