CDB25:0003368 COL11A1 — DDR2

Experimentally validated in Mixed species; Orthology-inferred in Human, Mouse, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

Collagen Type XI Inhibits Lung Cancer-Associated Fibroblast Functions and Restrains the Integrin Binding Site Availability on Collagen Type I Matrix.

International journal of molecular sciences, 2022; PubMed, Bos taurus COL11A1 — Homo sapiens DDR2

ABSTRACT: The tumor microenvironment, including cancer-associated fibroblast (CAF), plays an active role in non-small cell lung cancer (NSCLC) development and progression. We previously reported that collagen type XI and integrin α11, a collagen receptor, were upregulated in NSCLC; the latter promotes tumor growth and metastasis. We here explored the role of collagen type XI in NSCLC stroma. We showed that the presence of collagen type XI in collagen type I matrices inhibits CAF-mediated collagen remodeling and cell migration. This resulted in the inhibition of CAF-dependent lung-tumor cell invasion. Among the collagen receptors expressed on CAF, we determined that DDR2 and integrin α2β1, but not integrin α11β1, mediated the high-affinity binding to collagen type XI. We further demonstrated that collagen type XI restrained the integrin binding site availability on collagen type I matrices, thus limiting cell interaction with collagen type I. As a consequence, CAFs failed to activate FAK, p38 and Akt one hour after they interacted with collagen type I/XI. We concluded that collagen type XI may have a competitive negative feedback role on the binding of collagen type I to its receptors.

Basic Information on COL11A1

Ligand Name: collagen type XI alpha 1 chain

Other Symbols: COLL6, DFNA37, STL2, CO11A1

Ligand Location: secreted based on hpa, perplexity, uniprot

HGNC Gene Symbol Report: COL11A1

GeneCards: COL11A1

HGNC Gene Group: Collagens

Functional Annotations for COL11A1

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for COL11A1

COL11A1 — ITGA2 ・ COL11A1 — ITGB1

Basic Information on DDR2

Receptor Name: discoidin domain receptor tyrosine kinase 2

Other Symbols: TYRO10, NTRKR3, TKT

Receptor Location: cell membrane based on hpa, perplexity, uniprot

HGNC Gene Symbol Report: DDR2

GeneCards: DDR2

HGNC Gene Group: Receptor kinases

Functional Annotations for DDR2

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for DDR2

COL1A1 — DDR2 ・ COL3A1 — DDR2 ・ COL11A2 — DDR2 ・ COL1A2 — DDR2 ・ COL2A1 — DDR2 ・ COL4A1 — DDR2 ・ COL4A2 — DDR2 ・ COL4A3 — DDR2 ・ COL4A4 — DDR2 ・ COL4A5 — DDR2 ・ COL4A6 — DDR2 ・ COL5A1 — DDR2 ・ COL5A2 — DDR2 ・ COL5A3 — DDR2