CDB25:0003380 COL1A2 — DDR2

Experimentally validated in Human, Mixed species; Orthology-inferred in Human, Mouse, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

The discoidin domain receptor tyrosine kinases are activated by collagen.

Molecular cell, 1997; PubMed, Mus Musculus Col1a2 — Homo sapiens DDR2

ABSTRACT: Two mammalian receptor tyrosine kinases (DDR1 and DDR2) have extracellular domains closely related to a D. discoideum lectin, discoidin, required for cell aggregation. Here, we show that the mammalian DDR receptors bind and are activated by specific types of collagen. Stimulation of DDR receptor tyrosine kinase activity requires the native triple-helical structure of collagen and occurs over an extended period of time. Collagen activation of DDR1 induces phosphorylation of a docking site for the Shc phosphotyrosine binding domain, whose presence is controlled by alternative splicing. Activation of DDR2 by collagen results in the up-regulation of matrix metalloproteinase-1 expression. These results suggest that the discoidin-related DDR tyrosine kinases are novel collagen receptors with the potential to control cellular responses to the extracellular matrix.

An orphan receptor tyrosine kinase family whose members serve as nonintegrin collagen receptors.

Molecular cell, 1997; PubMed, Bos taurus COL1A2 — Homo sapiens DDR2

ABSTRACT: Mammalian cells constantly monitor and respond to a myriad of extracellular signals, often by using cell surface receptors. Two important classes of cell surface receptors include the receptor tyrosine kinases, which recognize peptide growth factors such as insulin, and the integrins, which most often mediate binding to components of the extracellular matrix. We report that the collagens serve as ligands for the previously orphan family of discoidin domain-containing receptor-like tyrosine kinases. The unexpected realization that an extracellular matrix molecule can directly serve as a ligand for receptor tyrosine kinases provides an example of ligands shared by integrins and receptor tyrosine kinases, and this finding seems likely to change prevailing views about the mechanisms by which cells perceive and respond to the extracellular matrix.

Basic Information on COL1A2

Ligand Name: collagen type I alpha 2 chain

Other Symbols: OI4

Ligand Location: secreted based on hpa, perplexity, uniprot

HGNC Gene Symbol Report: COL1A2

GeneCards: COL1A2

HGNC Gene Group: Collagens

Functional Annotations for COL1A2

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for COL1A2

COL1A2 — CD44 ・ COL1A2 — ITGA1 ・ COL1A2 — ITGA11 ・ COL1A2 — ITGA2 ・ COL1A2 — ITGB1 ・ COL1A2 — GP6 ・ COL1A2 — DDR1 ・ COL1A2 — OSCAR

Basic Information on DDR2

Receptor Name: discoidin domain receptor tyrosine kinase 2

Other Symbols: TYRO10, NTRKR3, TKT

Receptor Location: cell membrane based on hpa, perplexity, uniprot

HGNC Gene Symbol Report: DDR2

GeneCards: DDR2

HGNC Gene Group: Receptor kinases

Functional Annotations for DDR2

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for DDR2

COL1A1 — DDR2 ・ COL3A1 — DDR2 ・ COL11A1 — DDR2 ・ COL11A2 — DDR2 ・ COL2A1 — DDR2 ・ COL4A1 — DDR2 ・ COL4A2 — DDR2 ・ COL4A3 — DDR2 ・ COL4A4 — DDR2 ・ COL4A5 — DDR2 ・ COL4A6 — DDR2 ・ COL5A1 — DDR2 ・ COL5A2 — DDR2 ・ COL5A3 — DDR2