CDB25:0003404 COL4A4 — DDR2

Experimentally validated in Mixed species; Orthology-inferred in Human, Mouse, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

An orphan receptor tyrosine kinase family whose members serve as nonintegrin collagen receptors.

Molecular cell, 1997; PubMed, Mus Musculus Col4a4 — Homo sapiens DDR2

ABSTRACT: Mammalian cells constantly monitor and respond to a myriad of extracellular signals, often by using cell surface receptors. Two important classes of cell surface receptors include the receptor tyrosine kinases, which recognize peptide growth factors such as insulin, and the integrins, which most often mediate binding to components of the extracellular matrix. We report that the collagens serve as ligands for the previously orphan family of discoidin domain-containing receptor-like tyrosine kinases. The unexpected realization that an extracellular matrix molecule can directly serve as a ligand for receptor tyrosine kinases provides an example of ligands shared by integrins and receptor tyrosine kinases, and this finding seems likely to change prevailing views about the mechanisms by which cells perceive and respond to the extracellular matrix.

Basic Information on COL4A4

Ligand Name: collagen type IV alpha 4 chain

Other Symbols: CA44

Ligand Location: secreted based on uniprot

HGNC Gene Symbol Report: COL4A4

GeneCards: COL4A4

HGNC Gene Group: Collagens

Functional Annotations for COL4A4

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for COL4A4

COL4A4 — ITGA2 ・ COL4A4 — ITGB1 ・ COL4A4 — ADGRG6 ・ COL4A4 — DDR1

Basic Information on DDR2

Receptor Name: discoidin domain receptor tyrosine kinase 2

Other Symbols: TYRO10, NTRKR3, TKT

Receptor Location: cell membrane based on hpa, perplexity, uniprot

HGNC Gene Symbol Report: DDR2

GeneCards: DDR2

HGNC Gene Group: Receptor kinases

Functional Annotations for DDR2

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for DDR2

COL1A1 — DDR2 ・ COL3A1 — DDR2 ・ COL11A1 — DDR2 ・ COL11A2 — DDR2 ・ COL1A2 — DDR2 ・ COL2A1 — DDR2 ・ COL4A1 — DDR2 ・ COL4A2 — DDR2 ・ COL4A3 — DDR2 ・ COL4A5 — DDR2 ・ COL4A6 — DDR2 ・ COL5A1 — DDR2 ・ COL5A2 — DDR2 ・ COL5A3 — DDR2