CDB25:0003146 APP — AGER

Experimentally validated in Human; Orthology-inferred in Mouse, Rat, Frog, Zebrafish, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

RAGE and amyloid-beta peptide neurotoxicity in Alzheimer's disease.

Nature, 1996; PubMed, Homo sapiens APP — Homo sapiens AGER

ABSTRACT: Amyloid-beta peptide is central to the pathology of Alzheimer's disease, because it is neurotoxic--directly by inducing oxidant stress, and indirectly by activating microglia. A specific cell-surface acceptor site that could focus its effects on target cells has been postulated but not identified. Here we present evidence that the 'receptor for advanced glycation end products' (RAGE) is such a receptor, and that it mediates effects of the peptide on neurons and microglia. Increased expressing of RAGE in Alzheimer's disease brain indicates that it is relevant to the pathogenesis of neuronal dysfunction and death.

Basic Information on APP

Ligand Name: amyloid beta precursor protein

Other Symbols: AD1, alpha-sAPP

Ligand Location: secreted based on hpa, perplexity, uniprot, cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: APP

GeneCards: APP

HGNC Gene Group: Receptor ligands

Functional Annotations for APP

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for APP

APP — CD74 ・ APP — FPR2 ・ APP — GPC1 ・ APP — LRP1 ・ APP — ADRA2A ・ APP — APLP1 ・ APP — APLP2 ・ APP — CNTN3 ・ APP — CNTN4 ・ APP — CNTN5 ・ APP — DCC ・ APP — LRP10 ・ APP — LRP2 ・ APP — LRP4 ・ APP — LRP6 ・ APP — NOTCH1 ・ APP — NOTCH2 ・ APP — RPSA ・ APP — TRPC6

Basic Information on AGER

Receptor Name: advanced glycosylation end-product specific receptor

Other Symbols: RAGE, SCARJ1, sRAGE

Receptor Location: cell membrane based on hpa, perplexity, uniprot

HGNC Gene Symbol Report: AGER

GeneCards: AGER

HGNC Gene Group: Scavenger receptors, Immunoglobulin superfamily domain containing

Functional Annotations for AGER

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for AGER

HMGB1 — AGER ・ ITGAX — AGER ・ ITGB2 — AGER ・ S100A1 — AGER ・ S100A4 — AGER ・ S100A7 — AGER ・ S100A8 — AGER ・ S100A9 — AGER ・ S100B — AGER