CDB25:0004206 S100A4 — AGER

Experimentally validated in Human; Orthology-inferred in Mouse, Rat, Frog, Zebrafish, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

Increase in production of matrix metalloproteinase 13 by human articular chondrocytes due to stimulation with S100A4: Role of the receptor for advanced glycation end products.

Arthritis and rheumatism, 2006; PubMed, Homo sapiens S100A4 — Homo sapiens AGER

ABSTRACT: S100 proteins have been implicated in various inflammatory conditions, including arthritis. The aims of this study were to determine whether chondrocytes produce S100A4 and whether S100A4 can stimulate the production of matrix metalloproteinase 13 (MMP-13) by articular chondrocytes via receptor for advanced glycation end products (RAGE)-mediated signaling.

Basic Information on S100A4

Ligand Name: S100 calcium binding protein A4

Other Symbols: MTS1, CAPL, P9KA, 18A2, PEL98, 42A, FSP1

Ligand Location: secreted based on hpa, perplexity, uniprot

HGNC Gene Symbol Report: S100A4

GeneCards: S100A4

HGNC Gene Group: Epidermal differentiation complex, EF-hand domain containing

Functional Annotations for S100A4

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for S100A4

S100A4 — ANXA2 ・ S100A4 — CCR5 ・ S100A4 — CXCR3 ・ S100A4 — EGFR ・ S100A4 — EMB ・ S100A4 — ERBB3 ・ S100A4 — ERBB4 ・ S100A4 — TLR4

Basic Information on AGER

Receptor Name: advanced glycosylation end-product specific receptor

Other Symbols: RAGE, SCARJ1, sRAGE

Receptor Location: cell membrane based on hpa, perplexity, uniprot

HGNC Gene Symbol Report: AGER

GeneCards: AGER

HGNC Gene Group: Scavenger receptors, Immunoglobulin superfamily domain containing

Functional Annotations for AGER

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for AGER

APP — AGER ・ HMGB1 — AGER ・ ITGAX — AGER ・ ITGB2 — AGER ・ S100A1 — AGER ・ S100A7 — AGER ・ S100A8 — AGER ・ S100A9 — AGER ・ S100B — AGER