CDB15:0000080 APP — CD74

Experimentally validated in Human, Mouse; Orthology-inferred in Human, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep, Mouse

Title

Journal:; Year Published:

Abstract

CD74 interacts with APP and suppresses the production of Abeta.

Molecular neurodegeneration, 2009; PubMed, Homo sapiens APP — Homo sapiens CD74

ABSTRACT: Alzheimer disease (AD) is characterized by senile plaques, which are mainly composed of beta amyloid (Abeta) peptides. Abeta is cleaved off from amyloid precursor protein (APP) with consecutive proteolytic processing by beta-secretase and gamma-secretase.

APP-CD74 axis mediates endothelial cell-macrophage communication to promote kidney injury and fibrosis.

Frontiers in pharmacology, 2024; PubMed, Homo sapiens APP — Homo sapiens CD74

ABSTRACT: Kidney injuries often carry a grim prognosis, marked by fibrosis development, renal function loss, and macrophage involvement. Despite extensive research on macrophage polarization and its effects on other cells, like fibroblasts, limited attention has been paid to the influence of non-immune cells on macrophages. This study aims to address this gap by shedding light on the intricate dynamics and diversity of macrophages during renal injury and repair.

Basic Information on APP

Ligand Name: amyloid beta precursor protein

Other Symbols: AD1, alpha-sAPP

Ligand Location: secreted based on hpa, perplexity, uniprot, cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: APP

GeneCards: APP

HGNC Gene Group: Receptor ligands

Functional Annotations for APP

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for APP

APP — FPR2 ・ APP — GPC1 ・ APP — LRP1 ・ APP — ADRA2A ・ APP — AGER ・ APP — APLP1 ・ APP — APLP2 ・ APP — CNTN3 ・ APP — CNTN4 ・ APP — CNTN5 ・ APP — DCC ・ APP — LRP10 ・ APP — LRP2 ・ APP — LRP4 ・ APP — LRP6 ・ APP — NOTCH1 ・ APP — NOTCH2 ・ APP — RPSA ・ APP — TRPC6

Basic Information on CD74

Receptor Name: CD74 molecule

Other Symbols: DHLAG, CLIP

Receptor Location: cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: CD74

GeneCards: CD74

HGNC Gene Group: CD molecules

Functional Annotations for CD74

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for CD74

MIF — CD74 ・ TIMP1 — CD74